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• W2016124952 abstract "— Muscarinic cholinergic agonists increase cyclic GMP levels in a number of neural tissues. Since the rat hippocampus receives a cholinergic innervation from the septum, we decided to test whether cyclic GMP levels of the rat hippocampus are increased by bethanechol, a muscarinic cholinergic agonist. Incubation of rat hippocampi with varying concentrations of bethanechol showed that the increase in cyclic GMP levels is concentration-dependent, 500 pwbethanechol producing a maximum increase of 490% over control values. The bethanechol-evoked increases were blocked by the muscarinic antagonist atropine, and were calcium-dependent. It is concluded that at least some of the cells projecting to the rat hippocampus form muscarinic cholinergic synapses which act via a cyclic GMP-dependent mechanism." @default.
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• W2016124952 date "1979-12-01" @default.
• W2016124952 modified "2023-09-24" @default.
• W2016124952 title "MUSCARINIC CHOLINERGIC STIMULATION INCREASES CYCLIC GMP LEVELS IN RAT HIPPOCAMPUS" @default.
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• W2016124952 doi "https://doi.org/10.1111/j.1471-4159.1979.tb05260.x" @default.
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