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• W2016126072 abstract "The beneficial effects of beta blocking drugs in hypertension and heart failure are well known. However, this class of drugs is pharmacologically heterogeneous. In contrast to the non vasodilator betablockers like propranolol, atenolol or metoprolol which, in hypertension do not decrease intima media thinckness both in arterioles and large arteries, do not decrease arterial rigidity and can induce diabetes mellitus, the betablockers with vasodilating properties are beneficial on these parameters. Moreover, in heart failure, they more markedly decrease left ventricular workload than betablockers without any vascular relaxing effect and the results of SENIOR with nebivolol could suggest the beneficial role of NO on left ventricular dysfunction. Finally, the third generation betablockers, represented by celiprolol, carvedilol and nebivolol, have antioxidant properties which are probably implicated in their endothelial protective effects and in their absence of deleterious metabolic effects, effects which are probably of interest in term of protection of target organs during chronic treatment of hypertensive patients." @default.
• W2016126072 created "2016-06-24" @default.
• W2016126072 creator A5083709363 @default.
• W2016126072 date "2010-04-01" @default.
• W2016126072 modified "2023-09-26" @default.
• W2016126072 title "Dysfonction endothéliale : le rôle des bêtabloquants vasodilatateurs dans l’hypertension artérielle et l’insuffisance cardiaque chronique" @default.
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• W2016126072 doi "https://doi.org/10.1016/j.ancard.2010.03.001" @default.
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