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• W2016126437 abstract "In vitro, topographical and biophysical cues arising from the extracellular matrix (ECM) direct skeletal stem cell (SSC) commitment and differentiation. However, the mechanisms by which the SSC-ECM interface is regulated and the outcome of such interactions on stem cell fate in vivo remain unknown. Here we demonstrate that conditional deletion of the membrane-anchored metalloproteinase MT1-MMP (Mmp14) in mesenchymal progenitors, but not in committed osteoblasts, redirects SSC fate decisions from osteogenesis to adipo- and chondrogenesis. By effecting ECM remodeling, MT1-MMP regulates stem cell shape, thereby activating a β1-integrin/RhoGTPase signaling cascade and triggering the nuclear localization of the transcriptional coactivators YAP and TAZ, which serve to control SSC lineage commitment. These data identify a critical MT1-MMP/integrin/YAP/TAZ axis operative in the stem cell niche that oversees SSC fate determination." @default.
• W2016126437 created "2016-06-24" @default.
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• W2016126437 date "2013-05-01" @default.
• W2016126437 modified "2023-10-14" @default.
• W2016126437 title "MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis" @default.
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• W2016126437 doi "https://doi.org/10.1016/j.devcel.2013.04.011" @default.
• W2016126437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3736823" @default.
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