FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016127324> ?p ?o ?g. }

• W2016127324 endingPage "e1003274" @default.
• W2016127324 startingPage "e1003274" @default.
• W2016127324 abstract "All pancreatic endocrine cell types arise from a common endocrine precursor cell population, yet the molecular mechanisms that establish and maintain the unique gene expression programs of each endocrine cell lineage have remained largely elusive. Such knowledge would improve our ability to correctly program or reprogram cells to adopt specific endocrine fates. Here, we show that the transcription factor Nkx6.1 is both necessary and sufficient to specify insulin-producing beta cells. Heritable expression of Nkx6.1 in endocrine precursors of mice is sufficient to respecify non-beta endocrine precursors towards the beta cell lineage, while endocrine precursor- or beta cell-specific inactivation of Nkx6.1 converts beta cells to alternative endocrine lineages. Remaining insulin+ cells in conditional Nkx6.1 mutants fail to express the beta cell transcription factors Pdx1 and MafA and ectopically express genes found in non-beta endocrine cells. By showing that Nkx6.1 binds to and represses the alpha cell determinant Arx, we identify Arx as a direct target of Nkx6.1. Moreover, we demonstrate that Nkx6.1 and the Arx activator Isl1 regulate Arx transcription antagonistically, thus establishing competition between Isl1 and Nkx6.1 as a critical mechanism for determining alpha versus beta cell identity. Our findings establish Nkx6.1 as a beta cell programming factor and demonstrate that repression of alternative lineage programs is a fundamental principle by which beta cells are specified and maintained. Given the lack of Nkx6.1 expression and aberrant activation of non-beta endocrine hormones in human embryonic stem cell (hESC)–derived insulin+ cells, our study has significant implications for developing cell replacement therapies." @default.
• W2016127324 created "2016-06-24" @default.
• W2016127324 creator A5002669249 @default.
• W2016127324 creator A5007018046 @default.
• W2016127324 creator A5011531088 @default.
• W2016127324 creator A5012746992 @default.
• W2016127324 creator A5018530141 @default.
• W2016127324 creator A5029484954 @default.
• W2016127324 creator A5033463942 @default.
• W2016127324 creator A5043344689 @default.
• W2016127324 creator A5043840854 @default.
• W2016127324 creator A5061561620 @default.
• W2016127324 creator A5063849113 @default.
• W2016127324 creator A5085610048 @default.
• W2016127324 date "2013-01-31" @default.
• W2016127324 modified "2023-10-03" @default.
• W2016127324 title "Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity" @default.
• W2016127324 cites W1565835249 @default.
• W2016127324 cites W1593837562 @default.
• W2016127324 cites W1627567497 @default.
• W2016127324 cites W1830287761 @default.
• W2016127324 cites W1961434948 @default.
• W2016127324 cites W1985708072 @default.
• W2016127324 cites W1987690732 @default.
• W2016127324 cites W1995856733 @default.
• W2016127324 cites W2006017090 @default.
• W2016127324 cites W2016753357 @default.
• W2016127324 cites W2019938563 @default.
• W2016127324 cites W2020713821 @default.
• W2016127324 cites W2031631150 @default.
• W2016127324 cites W2032284140 @default.
• W2016127324 cites W2036334886 @default.
• W2016127324 cites W2041777158 @default.
• W2016127324 cites W2054361177 @default.
• W2016127324 cites W2057361172 @default.
• W2016127324 cites W2061574308 @default.
• W2016127324 cites W2063944873 @default.
• W2016127324 cites W2066729924 @default.
• W2016127324 cites W2067349147 @default.
• W2016127324 cites W2081668489 @default.
• W2016127324 cites W2087485736 @default.
• W2016127324 cites W2094035169 @default.
• W2016127324 cites W2100350743 @default.
• W2016127324 cites W2103391067 @default.
• W2016127324 cites W2104921582 @default.
• W2016127324 cites W2106004510 @default.
• W2016127324 cites W2106219965 @default.
• W2016127324 cites W2108394804 @default.
• W2016127324 cites W2109627278 @default.
• W2016127324 cites W2110760195 @default.
• W2016127324 cites W2110982118 @default.
• W2016127324 cites W2112754181 @default.
• W2016127324 cites W2126780067 @default.
• W2016127324 cites W2129092167 @default.
• W2016127324 cites W2135663646 @default.
• W2016127324 cites W2136585808 @default.
• W2016127324 cites W2137987484 @default.
• W2016127324 cites W2144825184 @default.
• W2016127324 cites W2146127531 @default.
• W2016127324 cites W2148078342 @default.
• W2016127324 cites W2160216824 @default.
• W2016127324 cites W2160400743 @default.
• W2016127324 cites W2163732061 @default.
• W2016127324 cites W2169745228 @default.
• W2016127324 cites W2171298096 @default.
• W2016127324 cites W2223979714 @default.
• W2016127324 cites W2323566388 @default.
• W2016127324 cites W4230095346 @default.
• W2016127324 doi "https://doi.org/10.1371/journal.pgen.1003274" @default.
• W2016127324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3561089" @default.
• W2016127324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23382704" @default.
• W2016127324 hasPublicationYear "2013" @default.
• W2016127324 type Work @default.
• W2016127324 sameAs 2016127324 @default.
• W2016127324 citedByCount "209" @default.
• W2016127324 countsByYear W20161273242012 @default.
• W2016127324 countsByYear W20161273242013 @default.
• W2016127324 countsByYear W20161273242014 @default.
• W2016127324 countsByYear W20161273242015 @default.
• W2016127324 countsByYear W20161273242016 @default.
• W2016127324 countsByYear W20161273242017 @default.
• W2016127324 countsByYear W20161273242018 @default.
• W2016127324 countsByYear W20161273242019 @default.
• W2016127324 countsByYear W20161273242020 @default.
• W2016127324 countsByYear W20161273242021 @default.
• W2016127324 countsByYear W20161273242022 @default.
• W2016127324 countsByYear W20161273242023 @default.
• W2016127324 crossrefType "journal-article" @default.
• W2016127324 hasAuthorship W2016127324A5002669249 @default.
• W2016127324 hasAuthorship W2016127324A5007018046 @default.
• W2016127324 hasAuthorship W2016127324A5011531088 @default.
• W2016127324 hasAuthorship W2016127324A5012746992 @default.
• W2016127324 hasAuthorship W2016127324A5018530141 @default.
• W2016127324 hasAuthorship W2016127324A5029484954 @default.
• W2016127324 hasAuthorship W2016127324A5033463942 @default.
• W2016127324 hasAuthorship W2016127324A5043344689 @default.
• W2016127324 hasAuthorship W2016127324A5043840854 @default.
• W2016127324 hasAuthorship W2016127324A5061561620 @default.

• next