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• W2016127514 abstract "The COP9 signalosome (CSN) is an evolutionarily conserved multiprotein complex with an essential role in the development of higher eukaryotes. CSN deconjugates the ubiquitin-related modifier NEDD8 from the cullin subunit of cullin-RING type E3 ubiquitin ligases (CRLs), and CSN-mediated cullin deneddylation is required for full CRL activity. Although several plant E3 CRL functions have been shown to be compromised in Arabidopsis csn mutants, none of these functions have so far been shown to limit growth in these mutants. Here, we examine the role of CSN in the context of the E3 ubiquitin ligase SCF(SLEEPY1 (SLY1)), which promotes gibberellic acid (GA)-dependent responses in Arabidopsis thaliana. We show that csn mutants are impaired in GA- and SCF(SLY1)-dependent germination and elongation growth, and we show that these defects correlate with an accumulation and reduced turnover of an SCF(SLY1)-degradation target, the DELLA protein REPRESSOR-OF-ga1-3 (RGA). Genetic interaction studies between csn mutants and loss-of-function alleles of RGA and its functional homologue GIBBERELLIC ACID INSENSITIVE (GAI) further reveal that RGA and GAI repress defects of germination in strong csn mutants. In addition, we find that these two DELLA proteins are largely responsible for the elongation defects of a weak csn5 mutant allele. We thus conclude that an impairment of SCF(SLY1) is at least in part causative for the germination and elongation defects of csn mutants, and suggest that DELLA proteins are major growth repressors in these mutants." @default.
• W2016127514 created "2016-06-24" @default.
• W2016127514 creator A5039542326 @default.
• W2016127514 creator A5048605661 @default.
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• W2016127514 date "2010-02-01" @default.
• W2016127514 modified "2023-10-17" @default.
• W2016127514 title "DELLA proteins restrain germination and elongation growth in Arabidopsis thaliana COP9 signalosome mutants" @default.
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• W2016127514 doi "https://doi.org/10.1016/j.ejcb.2009.12.001" @default.
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