Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016127680> ?p ?o ?g. }
- W2016127680 endingPage "589" @default.
- W2016127680 startingPage "580" @default.
- W2016127680 abstract "The matrix metalloproteinases (MMPs) are important enzymes that regulate developmental processes, maintain normal physiology in adulthood and have reparative roles at specific stages after an insult to the nervous system. Conversely, the concordant presence and significant upregulation of several MMP members in virtually all neurological conditions result in pathology. Thus, the MMPs have diverse functions, capable of mediating repair and recovery on the one hand and being involved in producing injury on the other. Therefore, targeting MMPs in neurological conditions has become a complicated challenge. This article highlights the beneficial roles of MMPs in normal and reparative processes within the nervous system and discusses the detriments of MMPs encountered in pathology. We review the availability of MMP inhibitors for clinical use and propose that an important consideration for these inhibitors is timing and duration of their use. With acute injuries where a massive upregulation of several MMPs are observed in the early periods after the insult, early and short-term use of broad spectrum MMP inhibitors would seem logical. In chronic conditions where recurrent insults to the CNS are accompanied by prolonged upregulation of MMPs, thereby necessitating the chronic use of medications, the beneficial effects of MMPs in repair may be compromised by the long-term application of MMP inhibitors. In this review we have used spinal cord injury and multiple sclerosis as examples of acute and chronic neurological conditions, respectively, and we consider the use of MMP inhibitors in these states." @default.
- W2016127680 created "2016-06-24" @default.
- W2016127680 creator A5060415030 @default.
- W2016127680 creator A5080084367 @default.
- W2016127680 creator A5080958470 @default.
- W2016127680 date "2007-10-01" @default.
- W2016127680 modified "2023-10-18" @default.
- W2016127680 title "Targeting MMPs in acute and chronic neurological conditions" @default.
- W2016127680 cites W1581404300 @default.
- W2016127680 cites W1619234695 @default.
- W2016127680 cites W1632883247 @default.
- W2016127680 cites W1635459918 @default.
- W2016127680 cites W1846608835 @default.
- W2016127680 cites W1908112684 @default.
- W2016127680 cites W1911664005 @default.
- W2016127680 cites W1964295882 @default.
- W2016127680 cites W1965533650 @default.
- W2016127680 cites W1965842265 @default.
- W2016127680 cites W1966103610 @default.
- W2016127680 cites W1966752305 @default.
- W2016127680 cites W1967453352 @default.
- W2016127680 cites W1968168664 @default.
- W2016127680 cites W1969710690 @default.
- W2016127680 cites W1970212238 @default.
- W2016127680 cites W1970881264 @default.
- W2016127680 cites W1972193858 @default.
- W2016127680 cites W1973681520 @default.
- W2016127680 cites W1974261989 @default.
- W2016127680 cites W1978053309 @default.
- W2016127680 cites W1981290690 @default.
- W2016127680 cites W1984483611 @default.
- W2016127680 cites W1987825791 @default.
- W2016127680 cites W1996353122 @default.
- W2016127680 cites W1996413321 @default.
- W2016127680 cites W2002771508 @default.
- W2016127680 cites W2003500892 @default.
- W2016127680 cites W2004488368 @default.
- W2016127680 cites W2005920859 @default.
- W2016127680 cites W2009021998 @default.
- W2016127680 cites W2010666032 @default.
- W2016127680 cites W2012497864 @default.
- W2016127680 cites W2013412099 @default.
- W2016127680 cites W2014971932 @default.
- W2016127680 cites W2015163495 @default.
- W2016127680 cites W2015177938 @default.
- W2016127680 cites W2016484384 @default.
- W2016127680 cites W2017331741 @default.
- W2016127680 cites W2017420045 @default.
- W2016127680 cites W2023250693 @default.
- W2016127680 cites W2024061399 @default.
- W2016127680 cites W2025584874 @default.
- W2016127680 cites W2030104330 @default.
- W2016127680 cites W2030776545 @default.
- W2016127680 cites W2033143327 @default.
- W2016127680 cites W2034260461 @default.
- W2016127680 cites W2034804703 @default.
- W2016127680 cites W2035779766 @default.
- W2016127680 cites W2041533977 @default.
- W2016127680 cites W2044841261 @default.
- W2016127680 cites W2046329404 @default.
- W2016127680 cites W2049031559 @default.
- W2016127680 cites W2049306696 @default.
- W2016127680 cites W2051171636 @default.
- W2016127680 cites W2052798492 @default.
- W2016127680 cites W2053043355 @default.
- W2016127680 cites W2054190000 @default.
- W2016127680 cites W2057512153 @default.
- W2016127680 cites W2060319440 @default.
- W2016127680 cites W2063885093 @default.
- W2016127680 cites W2069252203 @default.
- W2016127680 cites W2071359561 @default.
- W2016127680 cites W2072356550 @default.
- W2016127680 cites W2075748308 @default.
- W2016127680 cites W2079241115 @default.
- W2016127680 cites W2081863795 @default.
- W2016127680 cites W2085429548 @default.
- W2016127680 cites W2086372708 @default.
- W2016127680 cites W2090459889 @default.
- W2016127680 cites W2092092581 @default.
- W2016127680 cites W2097510913 @default.
- W2016127680 cites W2101646625 @default.
- W2016127680 cites W2102146294 @default.
- W2016127680 cites W2102179492 @default.
- W2016127680 cites W2102651437 @default.
- W2016127680 cites W2105028929 @default.
- W2016127680 cites W2108565475 @default.
- W2016127680 cites W2117308838 @default.
- W2016127680 cites W2117751925 @default.
- W2016127680 cites W2122934527 @default.
- W2016127680 cites W2128049766 @default.
- W2016127680 cites W2130537267 @default.
- W2016127680 cites W2134405458 @default.
- W2016127680 cites W2135585199 @default.
- W2016127680 cites W2141726770 @default.
- W2016127680 cites W2145557612 @default.
- W2016127680 cites W2147362791 @default.
- W2016127680 cites W2155093913 @default.
- W2016127680 cites W2158692407 @default.