FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016127716> ?p ?o ?g. }

• W2016127716 endingPage "e89380" @default.
• W2016127716 startingPage "e89380" @default.
• W2016127716 abstract "Tumor heterogeneity is widely considered to be a determinant factor in tumor progression and in particular in its recurrence after therapy. Unfortunately, current medical techniques are unable to deduce clinically relevant information about tumor heterogeneity by means of non-invasive methods. As a consequence, when radiotherapy is used as a treatment of choice, radiation dosimetries are prescribed under the assumption that the malignancy targeted is of a homogeneous nature. In this work we discuss the effects of different radiation dose distributions on heterogeneous tumors by means of an individual cell-based model. To that end, a case is considered where two tumor cell phenotypes are present, which we assume to strongly differ in their respective cell cycle duration and radiosensitivity properties. We show herein that, as a result of such differences, the spatial distribution of the corresponding phenotypes, whence the resulting tumor heterogeneity can be predicted as growth proceeds. In particular, we show that if we start from a situation where a majority of ordinary cancer cells (CCs) and a minority of cancer stem cells (CSCs) are randomly distributed, and we assume that the length of CSC cycle is significantly longer than that of CCs, then CSCs become concentrated at an inner region as tumor grows. As a consequence we obtain that if CSCs are assumed to be more resistant to radiation than CCs, heterogeneous dosimetries can be selected to enhance tumor control by boosting radiation in the region occupied by the more radioresistant tumor cell phenotype. It is also shown that, when compared with homogeneous dose distributions as those being currently delivered in clinical practice, such heterogeneous radiation dosimetries fare always better than their homogeneous counterparts. Finally, limitations to our assumptions and their resulting clinical implications will be discussed." @default.
• W2016127716 created "2016-06-24" @default.
• W2016127716 creator A5023409487 @default.
• W2016127716 creator A5030752234 @default.
• W2016127716 creator A5031907453 @default.
• W2016127716 creator A5038118726 @default.
• W2016127716 creator A5063334043 @default.
• W2016127716 date "2014-02-26" @default.
• W2016127716 modified "2023-10-13" @default.
• W2016127716 title "Estimating Dose Painting Effects in Radiotherapy: A Mathematical Model" @default.
• W2016127716 cites W1520737046 @default.
• W2016127716 cites W1529775859 @default.
• W2016127716 cites W1544851750 @default.
• W2016127716 cites W1566664852 @default.
• W2016127716 cites W1893379941 @default.
• W2016127716 cites W1965406763 @default.
• W2016127716 cites W1966270769 @default.
• W2016127716 cites W1971747664 @default.
• W2016127716 cites W1973548147 @default.
• W2016127716 cites W1973592935 @default.
• W2016127716 cites W1974059924 @default.
• W2016127716 cites W1975641037 @default.
• W2016127716 cites W1982415526 @default.
• W2016127716 cites W1985148439 @default.
• W2016127716 cites W1985760249 @default.
• W2016127716 cites W1987012261 @default.
• W2016127716 cites W1987970790 @default.
• W2016127716 cites W1991133624 @default.
• W2016127716 cites W1992514491 @default.
• W2016127716 cites W1994320675 @default.
• W2016127716 cites W1994700716 @default.
• W2016127716 cites W1994851899 @default.
• W2016127716 cites W1996269383 @default.
• W2016127716 cites W1997099893 @default.
• W2016127716 cites W1997203401 @default.
• W2016127716 cites W1998728654 @default.
• W2016127716 cites W1999356404 @default.
• W2016127716 cites W2000831561 @default.
• W2016127716 cites W2001613409 @default.
• W2016127716 cites W2002903734 @default.
• W2016127716 cites W2004967542 @default.
• W2016127716 cites W2008878539 @default.
• W2016127716 cites W2009886857 @default.
• W2016127716 cites W2013395252 @default.
• W2016127716 cites W2017883800 @default.
• W2016127716 cites W2021048148 @default.
• W2016127716 cites W2023774039 @default.
• W2016127716 cites W2024506562 @default.
• W2016127716 cites W2025104440 @default.
• W2016127716 cites W2025633794 @default.
• W2016127716 cites W2029517266 @default.
• W2016127716 cites W2031348772 @default.
• W2016127716 cites W2035189255 @default.
• W2016127716 cites W2040458067 @default.
• W2016127716 cites W2041399543 @default.
• W2016127716 cites W2042512338 @default.
• W2016127716 cites W2043875880 @default.
• W2016127716 cites W2045434770 @default.
• W2016127716 cites W2046558067 @default.
• W2016127716 cites W2060551076 @default.
• W2016127716 cites W2061434030 @default.
• W2016127716 cites W2062643896 @default.
• W2016127716 cites W2065191902 @default.
• W2016127716 cites W2065456585 @default.
• W2016127716 cites W2072053496 @default.
• W2016127716 cites W2073213893 @default.
• W2016127716 cites W2076134474 @default.
• W2016127716 cites W2078510083 @default.
• W2016127716 cites W2082343402 @default.
• W2016127716 cites W2082608104 @default.
• W2016127716 cites W2083337908 @default.
• W2016127716 cites W2087162196 @default.
• W2016127716 cites W2088838124 @default.
• W2016127716 cites W2090874021 @default.
• W2016127716 cites W2094650757 @default.
• W2016127716 cites W2095921114 @default.
• W2016127716 cites W2097512974 @default.
• W2016127716 cites W2100640599 @default.
• W2016127716 cites W2105054044 @default.
• W2016127716 cites W2105199817 @default.
• W2016127716 cites W2108835820 @default.
• W2016127716 cites W2108897653 @default.
• W2016127716 cites W2111663010 @default.
• W2016127716 cites W2117079953 @default.
• W2016127716 cites W2120986496 @default.
• W2016127716 cites W2120991581 @default.
• W2016127716 cites W2130541529 @default.
• W2016127716 cites W2139899744 @default.
• W2016127716 cites W2149935273 @default.
• W2016127716 cites W2150575159 @default.
• W2016127716 cites W2151098840 @default.
• W2016127716 cites W2151948621 @default.
• W2016127716 cites W2153563443 @default.
• W2016127716 cites W2155076236 @default.
• W2016127716 cites W2155418451 @default.
• W2016127716 cites W2157195219 @default.
• W2016127716 cites W2160138651 @default.
• W2016127716 cites W2162920700 @default.

• next