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- W2016128323 abstract "The EWS/FLI-1 fusion gene, resulting from a t(11;22) translocation, plays a key role in the pathogenesis of Ewing's sarcoma. We demonstrate the presence of EWS/FLI-1 hybrid transcripts also in giant-cell tumor, a bone neoplasm featuring intermediate characteristics between benign and malignant lesions. Chimeric products were detected by semi-nested PCR after 2 cycles of amplification in 13/15 cases of giant-cell tumor, and their presence was confirmed by Southern and Western blots and fluorescence in situ hybridization. Moreover, 3/8 primary cultures of giant-cell tumor showed the same type of hybrid transcript observed in the original tumor sample. Sequencing of PCR products confirmed the presence of EWS and FLI-1 sequences in these products. Detection of EWS/FLI-1 fusion transcripts in giant-cell tumor of bone provides a model for the study of the transforming mechanisms of the EWS/FLI-1 fusion gene in mesenchymal tumors. Int. J. Cancer 87:328–335, 2000. © 2000 Wiley-Liss, Inc." @default.
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- W2016128323 date "2000-01-01" @default.
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- W2016128323 title "Identification of EWS/FLI-1 transcripts in giant-cell tumor of bone" @default.
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- W2016128323 doi "https://doi.org/10.1002/1097-0215(20000801)87:3<328::aid-ijc4>3.0.co;2-1" @default.
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