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• W2016128621 abstract "Recent evidence suggests a role for vitamin D in pathogenesis and prevention of diabetes mellitus. Active vitamin D, 1α,25(OH)2D3, prevents type 1 diabetes in animal models, modifies T-cell differentiation, modulates dendritic cell action and induces cytokine secretion, shifting the balance to regulatory T cells. High-dose vitamin D supplementation early in life protects against type 1 diabetes. 1α,25(OH)2D3 activity is mediated through its receptor, and targets include transcriptional regulators; therefore, 1α,25(OH)2D3 influences gene transcription. 1α,25(OH)2D3 also affects pancreatic β-cell function. Genomic variations of vitamin D metabolism and target cell action predispose to type 1 diabetes. Vitamin D deficiency in pregnancy probably increases the incidence of autoimmune diseases, such as type 1 diabetes, in genetically predisposed individuals. Pharmacotherapy with 1α,25(OH)2D3 analogues might help prevent and treat diabetes. Recent evidence suggests a role for vitamin D in pathogenesis and prevention of diabetes mellitus. Active vitamin D, 1α,25(OH)2D3, prevents type 1 diabetes in animal models, modifies T-cell differentiation, modulates dendritic cell action and induces cytokine secretion, shifting the balance to regulatory T cells. High-dose vitamin D supplementation early in life protects against type 1 diabetes. 1α,25(OH)2D3 activity is mediated through its receptor, and targets include transcriptional regulators; therefore, 1α,25(OH)2D3 influences gene transcription. 1α,25(OH)2D3 also affects pancreatic β-cell function. Genomic variations of vitamin D metabolism and target cell action predispose to type 1 diabetes. Vitamin D deficiency in pregnancy probably increases the incidence of autoimmune diseases, such as type 1 diabetes, in genetically predisposed individuals. Pharmacotherapy with 1α,25(OH)2D3 analogues might help prevent and treat diabetes." @default.
• W2016128621 created "2016-06-24" @default.
• W2016128621 creator A5025448215 @default.
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• W2016128621 date "2005-08-01" @default.
• W2016128621 modified "2023-10-11" @default.
• W2016128621 title "Vitamin D and type 1 diabetes mellitus: state of the art" @default.
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• W2016128621 doi "https://doi.org/10.1016/j.tem.2005.06.004" @default.
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