FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016130736> ?p ?o ?g. }

• W2016130736 endingPage "5065" @default.
• W2016130736 startingPage "5061" @default.
• W2016130736 abstract "In nonpolarized cells, the small GTPase Rab5a is localized to the plasma membrane, clathrin-coated vesicles, and early endosomes. Rab5a is required for early endosome fusion in vitro and regulates transport between the plasma membrane and early endosomes, in vivo. In polarized epithelial cells endocytosis occurs from separate apical and basolateral plasma membrane domains. Internalized molecules are initially delivered to distinct apical or basolateral early endosomes. In vitro, apical early endosomes can readily fuse with one another but not with the basolateral endosomes and vice versa, thereby indicating that the apical and basolateral early endocytic pathways are controlled by distinct machineries. Here, we have investigated the localization and function of Rab5a in polarized epithelial cells. Confocal immunofluorescence microscopy on mouse kidney sections revealed association of the protein with the apical and basolateral plasma membrane domains and underlying structures. In polarized Madin-Darby canine kidney I cells, endogenous and overexpressed Rab5a have the same distribution. Moreover, overexpression of the protein causes a 2-fold increase in fluid-phase uptake from both domains of the cell, thus showing that Rab5a functions in apical and basolateral endocytosis. Our data indicate that the apical and basolateral endocytic machineries of epithelial cells share common regulatory components and that Rab5a per se is not sufficient to target endocytic vesicles to apical or basolateral early endosomes." @default.
• W2016130736 created "2016-06-24" @default.
• W2016130736 creator A5000258094 @default.
• W2016130736 creator A5012441246 @default.
• W2016130736 creator A5032947684 @default.
• W2016130736 creator A5055790068 @default.
• W2016130736 creator A5082655611 @default.
• W2016130736 creator A5089505241 @default.
• W2016130736 date "1994-05-24" @default.
• W2016130736 modified "2023-09-25" @default.
• W2016130736 title "Rab5a is a common component of the apical and basolateral endocytic machinery in polarized epithelial cells." @default.
• W2016130736 cites W1489777708 @default.
• W2016130736 cites W1536335250 @default.
• W2016130736 cites W158810188 @default.
• W2016130736 cites W1594236032 @default.
• W2016130736 cites W1606338704 @default.
• W2016130736 cites W1715587256 @default.
• W2016130736 cites W1873199501 @default.
• W2016130736 cites W1968395750 @default.
• W2016130736 cites W1976094538 @default.
• W2016130736 cites W1979752416 @default.
• W2016130736 cites W1984646224 @default.
• W2016130736 cites W1988420272 @default.
• W2016130736 cites W1988874966 @default.
• W2016130736 cites W1993638185 @default.
• W2016130736 cites W1996462307 @default.
• W2016130736 cites W1997691716 @default.
• W2016130736 cites W2001482496 @default.
• W2016130736 cites W2004788546 @default.
• W2016130736 cites W2005574904 @default.
• W2016130736 cites W2007797957 @default.
• W2016130736 cites W2013336934 @default.
• W2016130736 cites W2023090327 @default.
• W2016130736 cites W2025972769 @default.
• W2016130736 cites W2049620445 @default.
• W2016130736 cites W2056003065 @default.
• W2016130736 cites W2057087692 @default.
• W2016130736 cites W2058580752 @default.
• W2016130736 cites W2064916160 @default.
• W2016130736 cites W2065365365 @default.
• W2016130736 cites W2071008278 @default.
• W2016130736 cites W2071115686 @default.
• W2016130736 cites W2071427211 @default.
• W2016130736 cites W2079307547 @default.
• W2016130736 cites W2085680244 @default.
• W2016130736 cites W2090007293 @default.
• W2016130736 cites W2096744480 @default.
• W2016130736 cites W2114416733 @default.
• W2016130736 cites W2119608406 @default.
• W2016130736 cites W2120400070 @default.
• W2016130736 cites W2128474008 @default.
• W2016130736 cites W2128635872 @default.
• W2016130736 cites W2136513361 @default.
• W2016130736 cites W2140962689 @default.
• W2016130736 cites W2143062333 @default.
• W2016130736 cites W2149749269 @default.
• W2016130736 cites W2158519578 @default.
• W2016130736 cites W2158537601 @default.
• W2016130736 cites W2161545291 @default.
• W2016130736 cites W2164678697 @default.
• W2016130736 cites W2284518408 @default.
• W2016130736 cites W2467332253 @default.
• W2016130736 cites W4251805238 @default.
• W2016130736 cites W4290210261 @default.
• W2016130736 doi "https://doi.org/10.1073/pnas.91.11.5061" @default.
• W2016130736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/43931" @default.
• W2016130736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8197185" @default.
• W2016130736 hasPublicationYear "1994" @default.
• W2016130736 type Work @default.
• W2016130736 sameAs 2016130736 @default.
• W2016130736 citedByCount "112" @default.
• W2016130736 countsByYear W20161307362012 @default.
• W2016130736 countsByYear W20161307362013 @default.
• W2016130736 countsByYear W20161307362014 @default.
• W2016130736 countsByYear W20161307362015 @default.
• W2016130736 countsByYear W20161307362017 @default.
• W2016130736 countsByYear W20161307362018 @default.
• W2016130736 countsByYear W20161307362019 @default.
• W2016130736 countsByYear W20161307362022 @default.
• W2016130736 crossrefType "journal-article" @default.
• W2016130736 hasAuthorship W2016130736A5000258094 @default.
• W2016130736 hasAuthorship W2016130736A5012441246 @default.
• W2016130736 hasAuthorship W2016130736A5032947684 @default.
• W2016130736 hasAuthorship W2016130736A5055790068 @default.
• W2016130736 hasAuthorship W2016130736A5082655611 @default.
• W2016130736 hasAuthorship W2016130736A5089505241 @default.
• W2016130736 hasBestOaLocation W20161307361 @default.
• W2016130736 hasConcept C102747710 @default.
• W2016130736 hasConcept C130316041 @default.
• W2016130736 hasConcept C1491633281 @default.
• W2016130736 hasConcept C28005876 @default.
• W2016130736 hasConcept C3018436504 @default.
• W2016130736 hasConcept C39587587 @default.
• W2016130736 hasConcept C41625074 @default.
• W2016130736 hasConcept C49353375 @default.
• W2016130736 hasConcept C529295009 @default.
• W2016130736 hasConcept C54355233 @default.
• W2016130736 hasConcept C55493867 @default.

• next