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- W2016133156 abstract "We investigated the effects of cataractogenesis on phospholipid (P-lipid) synthesis in sugar cataracts from galactosemic rats and in hereditary cataracts from 13/N guinea pigs. Cataractous lenses from rats fed a 50% galactose diet for 7 days were incubated 24 h with radiolabeled choline or ethanolamine and the P-lipids were extracted. The galactosemic cataracts synthesized twice as much phosphatidylcholine (PtdCho) as control rat lenses, and phosphatidylethanolamine synthesis also was increased. Similar analysis of cataractous lenses from 3-week-old 13/N guinea pigs showed a 3-fold increase in PtdCho synthesis compared with control lenses. In all cases, the P-lipid precursor pool was lower in cataracts than in control lenses. The increased P-lipid synthesis in these cataracts may represent a membrane repair response to cataractogenic stress." @default.
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- W2016133156 date "2005-01-01" @default.
- W2016133156 modified "2023-09-26" @default.
- W2016133156 title "Effects of Cataractogenesis on the CDP-Choline Pathway: Increased Phospholipid Synthesis in Lenses from Galactosemic Rats and 13/N Guinea Pigs" @default.
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- W2016133156 doi "https://doi.org/10.1159/000082764" @default.
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