Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016133306> ?p ?o ?g. }
- W2016133306 endingPage "7533" @default.
- W2016133306 startingPage "7521" @default.
- W2016133306 abstract "Abstract Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits antineoplastic activity in experimental models and has been reported to reduce cancer incidence in diabetics. There are ongoing clinical trials to evaluate its antitumor properties, which may relate to its fundamental activity as an inhibitor of oxidative phosphorylation. Here, we show that serine withdrawal increases the antineoplastic effects of phenformin (a potent biguanide structurally related to metformin). Serine synthesis was not inhibited by biguanides. Instead, metabolic studies indicated a requirement for serine to allow cells to compensate for biguanide-induced decrease in oxidative phosphorylation by upregulating glycolysis. Furthermore, serine deprivation modified the impact of metformin on the relative abundance of metabolites within the citric acid cycle. In mice, a serine-deficient diet reduced serine levels in tumors and significantly enhanced the tumor growth–inhibitory actions of biguanide treatment. Our results define a dietary manipulation that can enhance the efficacy of biguanides as antineoplastic agents that target cancer cell energy metabolism. Cancer Res; 74(24); 7521–33. ©2014 AACR." @default.
- W2016133306 created "2016-06-24" @default.
- W2016133306 creator A5005616347 @default.
- W2016133306 creator A5011530890 @default.
- W2016133306 creator A5035883116 @default.
- W2016133306 creator A5044315228 @default.
- W2016133306 creator A5048843465 @default.
- W2016133306 creator A5061545003 @default.
- W2016133306 creator A5067887370 @default.
- W2016133306 creator A5068822443 @default.
- W2016133306 creator A5079752291 @default.
- W2016133306 creator A5083273593 @default.
- W2016133306 date "2014-12-14" @default.
- W2016133306 modified "2023-10-17" @default.
- W2016133306 title "Serine Deprivation Enhances Antineoplastic Activity of Biguanides" @default.
- W2016133306 cites W1980181091 @default.
- W2016133306 cites W1982324715 @default.
- W2016133306 cites W1985079385 @default.
- W2016133306 cites W1991473393 @default.
- W2016133306 cites W1998771362 @default.
- W2016133306 cites W2002583208 @default.
- W2016133306 cites W2006978335 @default.
- W2016133306 cites W2010238890 @default.
- W2016133306 cites W2012442095 @default.
- W2016133306 cites W2013047715 @default.
- W2016133306 cites W2014460958 @default.
- W2016133306 cites W2019683289 @default.
- W2016133306 cites W2022899908 @default.
- W2016133306 cites W2026413615 @default.
- W2016133306 cites W2028743750 @default.
- W2016133306 cites W2039558597 @default.
- W2016133306 cites W2043585619 @default.
- W2016133306 cites W2043614750 @default.
- W2016133306 cites W2051522090 @default.
- W2016133306 cites W2064656431 @default.
- W2016133306 cites W2078190084 @default.
- W2016133306 cites W2080971278 @default.
- W2016133306 cites W2082564115 @default.
- W2016133306 cites W2092152920 @default.
- W2016133306 cites W2092340120 @default.
- W2016133306 cites W2097259163 @default.
- W2016133306 cites W2104696999 @default.
- W2016133306 cites W2108281860 @default.
- W2016133306 cites W2116516144 @default.
- W2016133306 cites W2119437574 @default.
- W2016133306 cites W2123014930 @default.
- W2016133306 cites W2126464915 @default.
- W2016133306 cites W2126524529 @default.
- W2016133306 cites W2135617839 @default.
- W2016133306 cites W2143681046 @default.
- W2016133306 cites W2145640842 @default.
- W2016133306 cites W2146654374 @default.
- W2016133306 cites W2146780639 @default.
- W2016133306 cites W2149343603 @default.
- W2016133306 cites W2152647938 @default.
- W2016133306 cites W2158076290 @default.
- W2016133306 cites W2160615487 @default.
- W2016133306 cites W2192730946 @default.
- W2016133306 cites W238923612 @default.
- W2016133306 cites W2988150099 @default.
- W2016133306 doi "https://doi.org/10.1158/0008-5472.can-14-2643-t" @default.
- W2016133306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25377470" @default.
- W2016133306 hasPublicationYear "2014" @default.
- W2016133306 type Work @default.
- W2016133306 sameAs 2016133306 @default.
- W2016133306 citedByCount "105" @default.
- W2016133306 countsByYear W20161333062015 @default.
- W2016133306 countsByYear W20161333062016 @default.
- W2016133306 countsByYear W20161333062017 @default.
- W2016133306 countsByYear W20161333062018 @default.
- W2016133306 countsByYear W20161333062019 @default.
- W2016133306 countsByYear W20161333062020 @default.
- W2016133306 countsByYear W20161333062021 @default.
- W2016133306 countsByYear W20161333062022 @default.
- W2016133306 countsByYear W20161333062023 @default.
- W2016133306 crossrefType "journal-article" @default.
- W2016133306 hasAuthorship W2016133306A5005616347 @default.
- W2016133306 hasAuthorship W2016133306A5011530890 @default.
- W2016133306 hasAuthorship W2016133306A5035883116 @default.
- W2016133306 hasAuthorship W2016133306A5044315228 @default.
- W2016133306 hasAuthorship W2016133306A5048843465 @default.
- W2016133306 hasAuthorship W2016133306A5061545003 @default.
- W2016133306 hasAuthorship W2016133306A5067887370 @default.
- W2016133306 hasAuthorship W2016133306A5068822443 @default.
- W2016133306 hasAuthorship W2016133306A5079752291 @default.
- W2016133306 hasAuthorship W2016133306A5083273593 @default.
- W2016133306 hasBestOaLocation W20161333061 @default.
- W2016133306 hasConcept C11960822 @default.
- W2016133306 hasConcept C121608353 @default.
- W2016133306 hasConcept C126322002 @default.
- W2016133306 hasConcept C134018914 @default.
- W2016133306 hasConcept C185592680 @default.
- W2016133306 hasConcept C2776414213 @default.
- W2016133306 hasConcept C2777688063 @default.
- W2016133306 hasConcept C2778877718 @default.
- W2016133306 hasConcept C2780323712 @default.
- W2016133306 hasConcept C55493867 @default.
- W2016133306 hasConcept C555293320 @default.