FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016134151> ?p ?o ?g. }

• W2016134151 endingPage "996" @default.
• W2016134151 startingPage "987" @default.
• W2016134151 abstract "Objective This study was undertaken to examine the neurofilament and neurochemical composition of subpopulations of primary afferent neurons innervating the levator ani muscle by combining retrograde tracing and triple labeling immunofluorescence in the female squirrel monkey. Study design Cholera toxin B subunit (CTB) was injected unilaterally into the levator ani muscle of 3 monkeys to identify primary sensory neurons in the dorsal root ganglia (DRG) and their central projections in the spinal cord. L7-S2 DRG were processed for dual or triple labeling immunofluorescence 3 days after injection to examine labeling of the 200 kD neurofilament marker RT97 (a marker of myelinated neurons), calcitonin gene-related peptide (CGRP; a marker of peptidergic neurons), isolectin B4 (IB4; a marker of small, unmyelinated neurons), and nerve growth factor receptor (TrkA) in CTB-positive neurons. Results RT97-negative (C-fiber) neurons were more numerous (74% of total CTB-labeled neurons) and smaller in size than RT97-positive (A-fiber) afferent neurons (26% of CTB-labeled neurons). IB4 labeling was almost exclusively found in RT97-negative afferent neurons. Approximately 43% of all CTB-labeled DRG neurons expressed CGRP, and the majority of these were small. The distribution and sizes of CTB-labeled TrkA-positive DRG neurons were similar to those of CTB-labeled CGRP-positive DRG neurons. Conclusion The levator ani muscle is innervated by 3 major subpopulations of primary afferent neurons consisting of cells with large, neurofilament-rich soma and A fibers (putative proprioceptive neurons) and those with small, peptidergic or nonpeptidergic, neurofilament-poor soma and C fibers (putative nociceptive, mechanoreceptive, ergoreceptive, and thermoreceptive neurons). Future investigation is needed to elucidate the relationship between primary sensory neuron subpopulations and changes in neuropeptide and neurotrophin expression on experimental levator ani nerve damage, childbirth, and aging. This study was undertaken to examine the neurofilament and neurochemical composition of subpopulations of primary afferent neurons innervating the levator ani muscle by combining retrograde tracing and triple labeling immunofluorescence in the female squirrel monkey. Cholera toxin B subunit (CTB) was injected unilaterally into the levator ani muscle of 3 monkeys to identify primary sensory neurons in the dorsal root ganglia (DRG) and their central projections in the spinal cord. L7-S2 DRG were processed for dual or triple labeling immunofluorescence 3 days after injection to examine labeling of the 200 kD neurofilament marker RT97 (a marker of myelinated neurons), calcitonin gene-related peptide (CGRP; a marker of peptidergic neurons), isolectin B4 (IB4; a marker of small, unmyelinated neurons), and nerve growth factor receptor (TrkA) in CTB-positive neurons. RT97-negative (C-fiber) neurons were more numerous (74% of total CTB-labeled neurons) and smaller in size than RT97-positive (A-fiber) afferent neurons (26% of CTB-labeled neurons). IB4 labeling was almost exclusively found in RT97-negative afferent neurons. Approximately 43% of all CTB-labeled DRG neurons expressed CGRP, and the majority of these were small. The distribution and sizes of CTB-labeled TrkA-positive DRG neurons were similar to those of CTB-labeled CGRP-positive DRG neurons. The levator ani muscle is innervated by 3 major subpopulations of primary afferent neurons consisting of cells with large, neurofilament-rich soma and A fibers (putative proprioceptive neurons) and those with small, peptidergic or nonpeptidergic, neurofilament-poor soma and C fibers (putative nociceptive, mechanoreceptive, ergoreceptive, and thermoreceptive neurons). Future investigation is needed to elucidate the relationship between primary sensory neuron subpopulations and changes in neuropeptide and neurotrophin expression on experimental levator ani nerve damage, childbirth, and aging." @default.
• W2016134151 created "2016-06-24" @default.
• W2016134151 creator A5003845584 @default.
• W2016134151 creator A5012519468 @default.
• W2016134151 creator A5023703205 @default.
• W2016134151 creator A5052338741 @default.
• W2016134151 creator A5053168837 @default.
• W2016134151 creator A5067035926 @default.
• W2016134151 creator A5074341199 @default.
• W2016134151 date "2006-10-01" @default.
• W2016134151 modified "2023-10-16" @default.
• W2016134151 title "Distribution and immunohistochemical characterization of primary afferent neurons innervating the levator ani muscle of the female squirrel monkey" @default.
• W2016134151 cites W1597738183 @default.
• W2016134151 cites W1966133712 @default.
• W2016134151 cites W1981697384 @default.
• W2016134151 cites W1994393960 @default.
• W2016134151 cites W2029895972 @default.
• W2016134151 cites W2038063686 @default.
• W2016134151 cites W2045032238 @default.
• W2016134151 cites W2054956674 @default.
• W2016134151 cites W2057083319 @default.
• W2016134151 cites W2061944529 @default.
• W2016134151 cites W2070667928 @default.
• W2016134151 cites W2075244021 @default.
• W2016134151 cites W2091450831 @default.
• W2016134151 cites W2107040951 @default.
• W2016134151 cites W2107571072 @default.
• W2016134151 cites W2112201877 @default.
• W2016134151 cites W2112382187 @default.
• W2016134151 cites W2123087817 @default.
• W2016134151 cites W2127295241 @default.
• W2016134151 cites W2154617206 @default.
• W2016134151 cites W2158649743 @default.
• W2016134151 doi "https://doi.org/10.1016/j.ajog.2006.02.042" @default.
• W2016134151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16635454" @default.
• W2016134151 hasPublicationYear "2006" @default.
• W2016134151 type Work @default.
• W2016134151 sameAs 2016134151 @default.
• W2016134151 citedByCount "20" @default.
• W2016134151 countsByYear W20161341512012 @default.
• W2016134151 countsByYear W20161341512014 @default.
• W2016134151 countsByYear W20161341512015 @default.
• W2016134151 countsByYear W20161341512016 @default.
• W2016134151 countsByYear W20161341512017 @default.
• W2016134151 countsByYear W20161341512020 @default.
• W2016134151 countsByYear W20161341512022 @default.
• W2016134151 crossrefType "journal-article" @default.
• W2016134151 hasAuthorship W2016134151A5003845584 @default.
• W2016134151 hasAuthorship W2016134151A5012519468 @default.
• W2016134151 hasAuthorship W2016134151A5023703205 @default.
• W2016134151 hasAuthorship W2016134151A5052338741 @default.
• W2016134151 hasAuthorship W2016134151A5053168837 @default.
• W2016134151 hasAuthorship W2016134151A5067035926 @default.
• W2016134151 hasAuthorship W2016134151A5074341199 @default.
• W2016134151 hasConcept C105702510 @default.
• W2016134151 hasConcept C118303440 @default.
• W2016134151 hasConcept C126322002 @default.
• W2016134151 hasConcept C142724271 @default.
• W2016134151 hasConcept C157207234 @default.
• W2016134151 hasConcept C163170386 @default.
• W2016134151 hasConcept C169760540 @default.
• W2016134151 hasConcept C170493617 @default.
• W2016134151 hasConcept C204232928 @default.
• W2016134151 hasConcept C2776281502 @default.
• W2016134151 hasConcept C2778794669 @default.
• W2016134151 hasConcept C2780775167 @default.
• W2016134151 hasConcept C71924100 @default.
• W2016134151 hasConcept C86803240 @default.
• W2016134151 hasConceptScore W2016134151C105702510 @default.
• W2016134151 hasConceptScore W2016134151C118303440 @default.
• W2016134151 hasConceptScore W2016134151C126322002 @default.
• W2016134151 hasConceptScore W2016134151C142724271 @default.
• W2016134151 hasConceptScore W2016134151C157207234 @default.
• W2016134151 hasConceptScore W2016134151C163170386 @default.
• W2016134151 hasConceptScore W2016134151C169760540 @default.
• W2016134151 hasConceptScore W2016134151C170493617 @default.
• W2016134151 hasConceptScore W2016134151C204232928 @default.
• W2016134151 hasConceptScore W2016134151C2776281502 @default.
• W2016134151 hasConceptScore W2016134151C2778794669 @default.
• W2016134151 hasConceptScore W2016134151C2780775167 @default.
• W2016134151 hasConceptScore W2016134151C71924100 @default.
• W2016134151 hasConceptScore W2016134151C86803240 @default.
• W2016134151 hasIssue "4" @default.
• W2016134151 hasLocation W20161341511 @default.
• W2016134151 hasLocation W20161341512 @default.
• W2016134151 hasOpenAccess W2016134151 @default.
• W2016134151 hasPrimaryLocation W20161341511 @default.
• W2016134151 hasRelatedWork W1970433041 @default.
• W2016134151 hasRelatedWork W2038598689 @default.
• W2016134151 hasRelatedWork W2058963536 @default.
• W2016134151 hasRelatedWork W2066603437 @default.
• W2016134151 hasRelatedWork W2075292990 @default.
• W2016134151 hasRelatedWork W2087249891 @default.
• W2016134151 hasRelatedWork W2160584330 @default.
• W2016134151 hasRelatedWork W2350689067 @default.
• W2016134151 hasRelatedWork W2377095345 @default.
• W2016134151 hasRelatedWork W4233796978 @default.
• W2016134151 hasVolume "195" @default.

• next