FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016134309> ?p ?o ?g. }

• W2016134309 endingPage "1179" @default.
• W2016134309 startingPage "1175" @default.
• W2016134309 abstract "We previously reported that a novel hydrophilic gamma-tocopherol (gamma-Toc) derivative, gamma-tocopheryl-N,N-dimethylglycinate hydrochloride (gamma-TDMG) gets converted to the antioxidant gamma-Toc in skin. We also found that this derivative displayed greater bioavailability than gamma-Toc itself. In the present study, we determined whether gamma-TDMG could reduce UV-induced skin pigmentation in brownish guinea pigs. gamma-TDMG (0.1 or 0.5%) was topically applied to the skin before and after it was exposed to UVB plus UVA (3 times/week for 1 week), and then 10 times/week for 4 weeks thereafter. Treatment with 0.5% gamma-TDMG resulted in significant skin lightening (70% of the pigmentation of irradiated controls). We also found that melanin synthesis was dose-dependently inhibited by gamma-TDMG in murine B16 melanoma cells. When gamma-TDMG or kojic acid (250 microM) were added to homogenates of B16 melanoma cells, their tyrosinase activity was significantly inhibited by approximately 40% and 75%, respectively. Mushroom tyrosinase activity was significantly inhibited by 200 microM gamma-Toc and kojic acid, but not gamma-TDMG. When B16 cells were incubated with 250 microM gamma-TDMG for 24 or 48 h, their intracellular gamma-Toc concentrations rose over 100 fold to 10.5 and 11.2 nmol/10(6) cells, respectively, suggesting that gamma-TDMG was rapidly converted to gamma-Toc in these cells and that their reduced melanin synthesis may have been due to the activity of gamma-Toc. Our data further suggest that the topical application of gamma-TDMG may be efficacious in preventing photo-induced skin pigmentation in humans." @default.
• W2016134309 created "2016-06-24" @default.
• W2016134309 creator A5000806736 @default.
• W2016134309 creator A5011573500 @default.
• W2016134309 creator A5018768276 @default.
• W2016134309 creator A5022073552 @default.
• W2016134309 creator A5027748670 @default.
• W2016134309 creator A5031752109 @default.
• W2016134309 creator A5032256157 @default.
• W2016134309 creator A5038701304 @default.
• W2016134309 creator A5043031266 @default.
• W2016134309 creator A5065628739 @default.
• W2016134309 creator A5078189171 @default.
• W2016134309 date "2006-01-01" @default.
• W2016134309 modified "2023-10-14" @default.
• W2016134309 title "Topical Application of .GAMMA.-Tocopherol Derivative Prevents UV-Induced Skin Pigmentation" @default.
• W2016134309 cites W1865284955 @default.
• W2016134309 cites W1963769068 @default.
• W2016134309 cites W1973054250 @default.
• W2016134309 cites W1974574315 @default.
• W2016134309 cites W1975631118 @default.
• W2016134309 cites W1977979647 @default.
• W2016134309 cites W1979879403 @default.
• W2016134309 cites W1985729602 @default.
• W2016134309 cites W1999528046 @default.
• W2016134309 cites W2019013424 @default.
• W2016134309 cites W2031951021 @default.
• W2016134309 cites W2037829755 @default.
• W2016134309 cites W2042578571 @default.
• W2016134309 cites W2047241095 @default.
• W2016134309 cites W2047532620 @default.
• W2016134309 cites W2055334027 @default.
• W2016134309 cites W2056624564 @default.
• W2016134309 cites W2060644706 @default.
• W2016134309 cites W2061772020 @default.
• W2016134309 cites W2072207162 @default.
• W2016134309 cites W2081066000 @default.
• W2016134309 cites W2104364030 @default.
• W2016134309 cites W2115410479 @default.
• W2016134309 cites W2117698956 @default.
• W2016134309 cites W2130118714 @default.
• W2016134309 cites W2147538249 @default.
• W2016134309 cites W2157981391 @default.
• W2016134309 cites W2184282225 @default.
• W2016134309 cites W2481975277 @default.
• W2016134309 doi "https://doi.org/10.1248/bpb.29.1175" @default.
• W2016134309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16755012" @default.
• W2016134309 hasPublicationYear "2006" @default.
• W2016134309 type Work @default.
• W2016134309 sameAs 2016134309 @default.
• W2016134309 citedByCount "12" @default.
• W2016134309 countsByYear W20161343092014 @default.
• W2016134309 countsByYear W20161343092017 @default.
• W2016134309 countsByYear W20161343092018 @default.
• W2016134309 countsByYear W20161343092019 @default.
• W2016134309 countsByYear W20161343092020 @default.
• W2016134309 crossrefType "journal-article" @default.
• W2016134309 hasAuthorship W2016134309A5000806736 @default.
• W2016134309 hasAuthorship W2016134309A5011573500 @default.
• W2016134309 hasAuthorship W2016134309A5018768276 @default.
• W2016134309 hasAuthorship W2016134309A5022073552 @default.
• W2016134309 hasAuthorship W2016134309A5027748670 @default.
• W2016134309 hasAuthorship W2016134309A5031752109 @default.
• W2016134309 hasAuthorship W2016134309A5032256157 @default.
• W2016134309 hasAuthorship W2016134309A5038701304 @default.
• W2016134309 hasAuthorship W2016134309A5043031266 @default.
• W2016134309 hasAuthorship W2016134309A5065628739 @default.
• W2016134309 hasAuthorship W2016134309A5078189171 @default.
• W2016134309 hasBestOaLocation W20161343091 @default.
• W2016134309 hasConcept C107538193 @default.
• W2016134309 hasConcept C181199279 @default.
• W2016134309 hasConcept C181389837 @default.
• W2016134309 hasConcept C185592680 @default.
• W2016134309 hasConcept C2779078452 @default.
• W2016134309 hasConcept C2779538156 @default.
• W2016134309 hasConcept C45904493 @default.
• W2016134309 hasConcept C55493867 @default.
• W2016134309 hasConcept C86803240 @default.
• W2016134309 hasConcept C87554066 @default.
• W2016134309 hasConcept C98274493 @default.
• W2016134309 hasConceptScore W2016134309C107538193 @default.
• W2016134309 hasConceptScore W2016134309C181199279 @default.
• W2016134309 hasConceptScore W2016134309C181389837 @default.
• W2016134309 hasConceptScore W2016134309C185592680 @default.
• W2016134309 hasConceptScore W2016134309C2779078452 @default.
• W2016134309 hasConceptScore W2016134309C2779538156 @default.
• W2016134309 hasConceptScore W2016134309C45904493 @default.
• W2016134309 hasConceptScore W2016134309C55493867 @default.
• W2016134309 hasConceptScore W2016134309C86803240 @default.
• W2016134309 hasConceptScore W2016134309C87554066 @default.
• W2016134309 hasConceptScore W2016134309C98274493 @default.
• W2016134309 hasIssue "6" @default.
• W2016134309 hasLocation W20161343091 @default.
• W2016134309 hasLocation W20161343092 @default.
• W2016134309 hasOpenAccess W2016134309 @default.
• W2016134309 hasPrimaryLocation W20161343091 @default.
• W2016134309 hasRelatedWork W2096029565 @default.
• W2016134309 hasRelatedWork W2108074348 @default.

• next