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- W2016135040 abstract "The effect of route of administration on the induction of micronucleated polychromatic erythrocytes (MNPCEs) was examined. 6-Mercaptopurine monohydrate (6-MP) was administered intraperitoneally (i.p.) or orally (p.o.) to 2 strains of mice, MS/Ae and CD-1. From the results of an acute toxicity test and a pilot micronucleus test, the doses selected for the final micronucleus test were 12.5-100 mg/kg for the i.p. route and 25-200 mg/kg for the p.o. route. The sampling time was 48 h. Frequencies of MNPCEs increased dose-dependently by the i.p. route but peaked at 50 or 100 mg/kg for the p.o. route. 6-MP induced MNPCEs more efficiently after p.o. administration than after i.p. treatment in both strains." @default.
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- W2016135040 date "1989-08-01" @default.
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- W2016135040 title "Micronucleus test with 6-mercaptopurine monohydrate administered intraperitoneally and orally" @default.
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- W2016135040 doi "https://doi.org/10.1016/0165-1218(89)90083-9" @default.
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