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- W2016137206 abstract "Electrical stimulation of the dorsal raphe (DR) and ventral tegmental area (VTA) activates the fibres of the same reward pathway but the phenotype of this pathway and the direction of the reward-relevant fibres have not been determined. Here we report rewarding effects following activation of a DR-originating pathway consisting of vesicular glutamate transporter 3 (VGluT3) containing neurons that form asymmetric synapses onto VTA dopamine neurons that project to nucleus accumbens. Optogenetic VTA activation of this projection elicits AMPA-mediated synaptic excitatory currents in VTA mesoaccumbens dopaminergic neurons and causes dopamine release in nucleus accumbens. Activation also reinforces instrumental behaviour and establishes conditioned place preferences. These findings indicate that the DR–VGluT3 pathway to VTA utilizes glutamate as a neurotransmitter and is a substrate linking the DR—one of the most sensitive reward sites in the brain—to VTA dopaminergic neurons. Glutamatergic neurons project from the dorsal raphe to the ventral tegmental area, two brain areas strongly associated with addictive behaviour, however the functional significance of this connection remains unclear. Qi et al.show that optogenetic activation of this pathway conveys reward in mice." @default.
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- W2016137206 date "2014-11-12" @default.
- W2016137206 modified "2023-10-03" @default.
- W2016137206 title "A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons" @default.
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- W2016137206 doi "https://doi.org/10.1038/ncomms6390" @default.
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