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- W2016142084 abstract "Absorption studies have been performed in nine healthy volunteers. Plasma concentrations of naftidrofuryl have been compared following administration of a single dose in three modified release explorative hydrocolloid matrix tablets and in an aqueous solution. The solution and one matrix tablet contained 100 mg, whereas the other two matrix formulations contained 300 mg of the drug. The amount of hydrocolloids used in the matrix tablets was varied to produce different in vitro release rates. The relative extent of bioavailability from the 300 mg tablet with a rapid drug release in vitro was significantly reduced, while it was unchanged from tablets with a comparatively slower drug release. This suggests that the absorption process has a limited capacity, and that the drug release rate is not controlling the absorption at this dose level. In contrast, the in vivo release rate from the 100 mg tablet, estimated by means of numerical deconvolution, showed a close agreement with the in vitro data." @default.
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- W2016142084 date "1992-11-01" @default.
- W2016142084 modified "2023-09-27" @default.
- W2016142084 title "Biopharmaceutical studies of naftidrofuryl in hydrocolloid matrix tablets" @default.
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- W2016142084 doi "https://doi.org/10.1016/0378-5173(92)90247-y" @default.
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