Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016142664> ?p ?o ?g. }
- W2016142664 endingPage "838" @default.
- W2016142664 startingPage "830" @default.
- W2016142664 abstract "Synovial sarcomas are high-grade soft tissue neoplasms often characterized by a biphasic spindle and epithelioid cell morphology. The majority of synovial sarcomas harbor a specific chromosomal translocation in which the proximal portion of the SYT gene at chromosome 18q11 is fused to the distal portion of one of several duplicated SSX genes (most notably SSX1 and SSX2) at chromosome Xp11. SYT/SSX1 translocations are seen in nearly three times as many synovial sarcomas as SYT/SSX2 translocations. Although the SYT/SSX2 fusion is usually associated with the monophasic disease pattern, the SYT/SSX1 fusion is present in tumors with biphasic or monophasic patterns. The SYT/SSX1 fusion gene is associated with more aggressive tumor growth and poor outcome. Despite advances in the therapy of local disease, distant metastasis remains the predominant cause of death. Accordingly, there is a need for alternate therapies, such as those recently developed against the receptor tyrosine kinases, such as epidermal growth factor receptor (EGFR) and HER-2/neu.Archival specimens of synovial sarcoma (n=38) representing 30 patients were assessed for EGFR and HER-2/neu protein expression by standard immunohistochemical techniques. To validate the immunohistochemistry results, quantitative real-time polymerase chain reaction (Q-PCR) assays using either fresh and/or archival material was performed. The presence of gene amplification was determined by chromogenic in-situ hybridization.EGFR and HER-2/neu protein were detected by immunohistochemistry in 21 of 38 (55.3%) and 20 of 38 (52.6%) synovial specimens, respectively. EGFR immunoreactivity showed a granular and membranous pattern, whereas HER-2/neu immunoreactivity demonstrated only a membrane pattern. Coexpression was observed in 13 of 38 specimens (34.2%). HER-2/neu expression by immunohistochemistry in synovial sarcomas was restricted to tumors with the SYT/SSX1 translocations. Of 6 specimens with SSX2 translocation, none (0%) showed HER-2/neu immunoreactivity and 1 (17%) demonstrated EGFR expression. Q-PCR demonstrated the presence of mRNA for EGFR and HER-2/neu in 19 of 30 specimens (63.3%) and 22 of 30 specimens (73.3%), respectively. EGFR and HER-2/neu were expressed at low concentrations compared with the expression of glyceraldehyde 3-phosphate dehydrogenase (GAPDH). No evidence of gene amplification was observed.EGFR and HER-2/neu are expressed in the majority of patients with SYT/SSX1 synovial sarcomas, albeit at low levels. Treatment with tyrosine kinase inhibitors may represent appropriate alternate therapy for these patients." @default.
- W2016142664 created "2016-06-24" @default.
- W2016142664 creator A5004418792 @default.
- W2016142664 creator A5030234836 @default.
- W2016142664 creator A5035161034 @default.
- W2016142664 creator A5040450464 @default.
- W2016142664 creator A5053860329 @default.
- W2016142664 creator A5061209536 @default.
- W2016142664 creator A5066442021 @default.
- W2016142664 creator A5077701232 @default.
- W2016142664 creator A5085071675 @default.
- W2016142664 date "2005-01-01" @default.
- W2016142664 modified "2023-10-07" @default.
- W2016142664 title "Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma" @default.
- W2016142664 cites W1208928033 @default.
- W2016142664 cites W1517116833 @default.
- W2016142664 cites W1904016327 @default.
- W2016142664 cites W1921598063 @default.
- W2016142664 cites W1970207103 @default.
- W2016142664 cites W1970263740 @default.
- W2016142664 cites W1980314947 @default.
- W2016142664 cites W1984740535 @default.
- W2016142664 cites W1984838097 @default.
- W2016142664 cites W2023711780 @default.
- W2016142664 cites W2030261010 @default.
- W2016142664 cites W2031190564 @default.
- W2016142664 cites W2032359283 @default.
- W2016142664 cites W2032959192 @default.
- W2016142664 cites W2040291225 @default.
- W2016142664 cites W2049299149 @default.
- W2016142664 cites W2053488663 @default.
- W2016142664 cites W2077545099 @default.
- W2016142664 cites W2077723130 @default.
- W2016142664 cites W2081628846 @default.
- W2016142664 cites W2089487481 @default.
- W2016142664 cites W2100417824 @default.
- W2016142664 cites W2100716241 @default.
- W2016142664 cites W2101849511 @default.
- W2016142664 cites W2109391477 @default.
- W2016142664 cites W2112787636 @default.
- W2016142664 cites W2114373487 @default.
- W2016142664 cites W2114389974 @default.
- W2016142664 cites W2125730396 @default.
- W2016142664 cites W2135034679 @default.
- W2016142664 cites W2135734390 @default.
- W2016142664 cites W2139713460 @default.
- W2016142664 cites W2141393790 @default.
- W2016142664 cites W2143243534 @default.
- W2016142664 cites W2164578725 @default.
- W2016142664 cites W2165932947 @default.
- W2016142664 cites W2197467038 @default.
- W2016142664 cites W2328452031 @default.
- W2016142664 cites W4211127808 @default.
- W2016142664 cites W4294216491 @default.
- W2016142664 cites W51995314 @default.
- W2016142664 doi "https://doi.org/10.1002/cncr.20847" @default.
- W2016142664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15641030" @default.
- W2016142664 hasPublicationYear "2005" @default.
- W2016142664 type Work @default.
- W2016142664 sameAs 2016142664 @default.
- W2016142664 citedByCount "81" @default.
- W2016142664 countsByYear W20161426642012 @default.
- W2016142664 countsByYear W20161426642013 @default.
- W2016142664 countsByYear W20161426642014 @default.
- W2016142664 countsByYear W20161426642015 @default.
- W2016142664 countsByYear W20161426642016 @default.
- W2016142664 countsByYear W20161426642017 @default.
- W2016142664 countsByYear W20161426642018 @default.
- W2016142664 countsByYear W20161426642019 @default.
- W2016142664 countsByYear W20161426642020 @default.
- W2016142664 countsByYear W20161426642022 @default.
- W2016142664 crossrefType "journal-article" @default.
- W2016142664 hasAuthorship W2016142664A5004418792 @default.
- W2016142664 hasAuthorship W2016142664A5030234836 @default.
- W2016142664 hasAuthorship W2016142664A5035161034 @default.
- W2016142664 hasAuthorship W2016142664A5040450464 @default.
- W2016142664 hasAuthorship W2016142664A5053860329 @default.
- W2016142664 hasAuthorship W2016142664A5061209536 @default.
- W2016142664 hasAuthorship W2016142664A5066442021 @default.
- W2016142664 hasAuthorship W2016142664A5077701232 @default.
- W2016142664 hasAuthorship W2016142664A5085071675 @default.
- W2016142664 hasBestOaLocation W20161426642 @default.
- W2016142664 hasConcept C101544691 @default.
- W2016142664 hasConcept C104317684 @default.
- W2016142664 hasConcept C111829193 @default.
- W2016142664 hasConcept C121608353 @default.
- W2016142664 hasConcept C123894998 @default.
- W2016142664 hasConcept C126322002 @default.
- W2016142664 hasConcept C138626823 @default.
- W2016142664 hasConcept C142724271 @default.
- W2016142664 hasConcept C150194340 @default.
- W2016142664 hasConcept C170493617 @default.
- W2016142664 hasConcept C204232928 @default.
- W2016142664 hasConcept C2776643354 @default.
- W2016142664 hasConcept C2776910622 @default.
- W2016142664 hasConcept C2778256501 @default.
- W2016142664 hasConcept C2779438470 @default.
- W2016142664 hasConcept C2779998722 @default.