FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016146739> ?p ?o ?g. }

• W2016146739 endingPage "3535" @default.
• W2016146739 startingPage "3525" @default.
• W2016146739 abstract "In this study we investigated the regulation of CXCR1 and CXCR2 intracellular trafficking. First, we produced a chimeric CXCR2 receptor that contained the internalization motifs of both CXCR2 and CXCR1 (CXCR2: LLKIL sequence; CXCR1: C-terminal phosphorylation sites). Elevated levels of internalization were induced by different ELR-expressing CXC chemokines on the chimeric receptor, as compared to wild-type CXCR2. Analysis of inter-relationships between CXCR1 and CXCR2 during internalization indicated that the exposure of cells that expressed both CXCR1 and CXCR2 to CXCL8 or CXCL6 resulted in decreased levels of CXCR1 internalization as compared to those in cells that expressed only CXCR1. To characterize the role of actin-related components in CXCR1 and CXCR2 trafficking, wortmannin, a potent inhibitor of phosphatidylinositol kinases, was used. The presence of wortmannin during receptor recycling inhibited CXCR1 and CXCR2 re-expression following CXCL8-induced internalization, and resulted in a marked disruption of the proper organization of actin filaments. The kinase-dependent recycling process required CXCR2 C-terminal phosphorylation sites. Our results suggest that actin-related kinases are required for the proper functionality of actin filaments, which are the instrumental factors needed for receptor recycling. In all, CXCR1 and CXCR2 internalization and recycling are tightly regulated by receptor domains and by actin-related kinases." @default.
• W2016146739 created "2016-06-24" @default.
• W2016146739 creator A5029299639 @default.
• W2016146739 creator A5034515566 @default.
• W2016146739 creator A5035966269 @default.
• W2016146739 creator A5052313653 @default.
• W2016146739 creator A5083223140 @default.
• W2016146739 date "2002-12-01" @default.
• W2016146739 modified "2023-09-25" @default.
• W2016146739 title "Intracellular trafficking of human CXCR1 and CXCR2: regulation by receptor domains and actin-related kinases" @default.
• W2016146739 cites W1506049383 @default.
• W2016146739 cites W1507084693 @default.
• W2016146739 cites W1512080499 @default.
• W2016146739 cites W1532806133 @default.
• W2016146739 cites W1585888204 @default.
• W2016146739 cites W1750158760 @default.
• W2016146739 cites W1975228050 @default.
• W2016146739 cites W1977412572 @default.
• W2016146739 cites W1979669507 @default.
• W2016146739 cites W1983377532 @default.
• W2016146739 cites W1993134838 @default.
• W2016146739 cites W2001525331 @default.
• W2016146739 cites W2020481017 @default.
• W2016146739 cites W2022669416 @default.
• W2016146739 cites W2034146282 @default.
• W2016146739 cites W2054437732 @default.
• W2016146739 cites W2058722504 @default.
• W2016146739 cites W2065674919 @default.
• W2016146739 cites W2071757447 @default.
• W2016146739 cites W2077399951 @default.
• W2016146739 cites W2081455644 @default.
• W2016146739 cites W2083985288 @default.
• W2016146739 cites W2087147037 @default.
• W2016146739 cites W2094813666 @default.
• W2016146739 cites W2103642422 @default.
• W2016146739 cites W2128640800 @default.
• W2016146739 cites W2150597600 @default.
• W2016146739 cites W40039454 @default.
• W2016146739 doi "https://doi.org/10.1002/1521-4141(200212)32:12<3525::aid-immu3525>3.0.co;2-1" @default.
• W2016146739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12442335" @default.
• W2016146739 hasPublicationYear "2002" @default.
• W2016146739 type Work @default.
• W2016146739 sameAs 2016146739 @default.
• W2016146739 citedByCount "20" @default.
• W2016146739 countsByYear W20161467392012 @default.
• W2016146739 countsByYear W20161467392013 @default.
• W2016146739 countsByYear W20161467392018 @default.
• W2016146739 countsByYear W20161467392019 @default.
• W2016146739 countsByYear W20161467392022 @default.
• W2016146739 crossrefType "journal-article" @default.
• W2016146739 hasAuthorship W2016146739A5029299639 @default.
• W2016146739 hasAuthorship W2016146739A5034515566 @default.
• W2016146739 hasAuthorship W2016146739A5035966269 @default.
• W2016146739 hasAuthorship W2016146739A5052313653 @default.
• W2016146739 hasAuthorship W2016146739A5083223140 @default.
• W2016146739 hasBestOaLocation W20161467391 @default.
• W2016146739 hasConcept C11960822 @default.
• W2016146739 hasConcept C125705527 @default.
• W2016146739 hasConcept C12823836 @default.
• W2016146739 hasConcept C13373296 @default.
• W2016146739 hasConcept C139770010 @default.
• W2016146739 hasConcept C142669718 @default.
• W2016146739 hasConcept C1491633281 @default.
• W2016146739 hasConcept C170493617 @default.
• W2016146739 hasConcept C184235292 @default.
• W2016146739 hasConcept C2778308172 @default.
• W2016146739 hasConcept C2780610907 @default.
• W2016146739 hasConcept C2993400109 @default.
• W2016146739 hasConcept C55493867 @default.
• W2016146739 hasConcept C84913492 @default.
• W2016146739 hasConcept C86803240 @default.
• W2016146739 hasConcept C95444343 @default.
• W2016146739 hasConceptScore W2016146739C11960822 @default.
• W2016146739 hasConceptScore W2016146739C125705527 @default.
• W2016146739 hasConceptScore W2016146739C12823836 @default.
• W2016146739 hasConceptScore W2016146739C13373296 @default.
• W2016146739 hasConceptScore W2016146739C139770010 @default.
• W2016146739 hasConceptScore W2016146739C142669718 @default.
• W2016146739 hasConceptScore W2016146739C1491633281 @default.
• W2016146739 hasConceptScore W2016146739C170493617 @default.
• W2016146739 hasConceptScore W2016146739C184235292 @default.
• W2016146739 hasConceptScore W2016146739C2778308172 @default.
• W2016146739 hasConceptScore W2016146739C2780610907 @default.
• W2016146739 hasConceptScore W2016146739C2993400109 @default.
• W2016146739 hasConceptScore W2016146739C55493867 @default.
• W2016146739 hasConceptScore W2016146739C84913492 @default.
• W2016146739 hasConceptScore W2016146739C86803240 @default.
• W2016146739 hasConceptScore W2016146739C95444343 @default.
• W2016146739 hasIssue "12" @default.
• W2016146739 hasLocation W20161467391 @default.
• W2016146739 hasLocation W20161467392 @default.
• W2016146739 hasOpenAccess W2016146739 @default.
• W2016146739 hasPrimaryLocation W20161467391 @default.
• W2016146739 hasRelatedWork W1512080499 @default.
• W2016146739 hasRelatedWork W1667563338 @default.
• W2016146739 hasRelatedWork W1982088642 @default.
• W2016146739 hasRelatedWork W1991471794 @default.
• W2016146739 hasRelatedWork W2016146739 @default.

• next