Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016148607> ?p ?o ?g. }
- W2016148607 endingPage "310" @default.
- W2016148607 startingPage "297" @default.
- W2016148607 abstract "The H3K4me3 mark in chromatin is closely correlated with actively transcribed genes, although the mechanisms involved in its generation and function are not fully understood. In vitro studies with recombinant chromatin and purified human factors demonstrate a robust SET1 complex (SET1C)-mediated H3K4 trimethylation that is dependent upon p53- and p300-mediated H3 acetylation, a corresponding SET1C-mediated enhancement of p53- and p300-dependent transcription that reflects a primary effect of SET1C through H3K4 trimethylation, and direct SET1C-p53 and SET1C-p300 interactions indicative of a targeted recruitment mechanism. Complementary cell-based assays demonstrate a DNA-damage-induced p53-SET1C interaction, a corresponding enrichment of SET1C and H3K4me3 on a p53 target gene (p21/WAF1), and a corresponding codependency of H3K4 trimethylation and transcription upon p300 and SET1C. These results establish a mechanism in which SET1C and p300 act cooperatively, through direct interactions and coupled histone modifications, to facilitate the function of p53." @default.
- W2016148607 created "2016-06-24" @default.
- W2016148607 creator A5004038379 @default.
- W2016148607 creator A5007755251 @default.
- W2016148607 creator A5031060352 @default.
- W2016148607 creator A5036257218 @default.
- W2016148607 creator A5042296036 @default.
- W2016148607 creator A5044973255 @default.
- W2016148607 creator A5055954909 @default.
- W2016148607 creator A5059609678 @default.
- W2016148607 creator A5074727195 @default.
- W2016148607 creator A5075707554 @default.
- W2016148607 creator A5084237230 @default.
- W2016148607 date "2013-07-01" @default.
- W2016148607 modified "2023-10-12" @default.
- W2016148607 title "SET1 and p300 Act Synergistically, through Coupled Histone Modifications, in Transcriptional Activation by p53" @default.
- W2016148607 cites W1519516387 @default.
- W2016148607 cites W1707745162 @default.
- W2016148607 cites W1766348042 @default.
- W2016148607 cites W1971974133 @default.
- W2016148607 cites W1974631163 @default.
- W2016148607 cites W1976645829 @default.
- W2016148607 cites W1982315838 @default.
- W2016148607 cites W1987569789 @default.
- W2016148607 cites W1991487490 @default.
- W2016148607 cites W1992213480 @default.
- W2016148607 cites W1992662525 @default.
- W2016148607 cites W1993243592 @default.
- W2016148607 cites W1996635747 @default.
- W2016148607 cites W2001311465 @default.
- W2016148607 cites W2009403023 @default.
- W2016148607 cites W2016058704 @default.
- W2016148607 cites W2017050785 @default.
- W2016148607 cites W2023096418 @default.
- W2016148607 cites W2024584416 @default.
- W2016148607 cites W2025722611 @default.
- W2016148607 cites W2030197516 @default.
- W2016148607 cites W2032594275 @default.
- W2016148607 cites W2043677605 @default.
- W2016148607 cites W2046079276 @default.
- W2016148607 cites W2046273050 @default.
- W2016148607 cites W2046717651 @default.
- W2016148607 cites W2054205113 @default.
- W2016148607 cites W2061372269 @default.
- W2016148607 cites W2068078666 @default.
- W2016148607 cites W2070867144 @default.
- W2016148607 cites W2075052598 @default.
- W2016148607 cites W2076430269 @default.
- W2016148607 cites W2084719919 @default.
- W2016148607 cites W2090919497 @default.
- W2016148607 cites W2092912586 @default.
- W2016148607 cites W2096083625 @default.
- W2016148607 cites W2108124310 @default.
- W2016148607 cites W2111793840 @default.
- W2016148607 cites W2118542750 @default.
- W2016148607 cites W2120100277 @default.
- W2016148607 cites W2120628024 @default.
- W2016148607 cites W2121836670 @default.
- W2016148607 cites W2121910267 @default.
- W2016148607 cites W2125236946 @default.
- W2016148607 cites W2125695802 @default.
- W2016148607 cites W2129608054 @default.
- W2016148607 cites W2133452708 @default.
- W2016148607 cites W2133959309 @default.
- W2016148607 cites W2137984821 @default.
- W2016148607 cites W2143471382 @default.
- W2016148607 cites W2145763664 @default.
- W2016148607 cites W2147690311 @default.
- W2016148607 cites W2150090219 @default.
- W2016148607 cites W2158074192 @default.
- W2016148607 cites W2158673140 @default.
- W2016148607 cites W2168012760 @default.
- W2016148607 cites W2168602111 @default.
- W2016148607 cites W4210384175 @default.
- W2016148607 doi "https://doi.org/10.1016/j.cell.2013.06.027" @default.
- W2016148607 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4023349" @default.
- W2016148607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23870121" @default.
- W2016148607 hasPublicationYear "2013" @default.
- W2016148607 type Work @default.
- W2016148607 sameAs 2016148607 @default.
- W2016148607 citedByCount "149" @default.
- W2016148607 countsByYear W20161486072013 @default.
- W2016148607 countsByYear W20161486072014 @default.
- W2016148607 countsByYear W20161486072015 @default.
- W2016148607 countsByYear W20161486072016 @default.
- W2016148607 countsByYear W20161486072017 @default.
- W2016148607 countsByYear W20161486072018 @default.
- W2016148607 countsByYear W20161486072019 @default.
- W2016148607 countsByYear W20161486072020 @default.
- W2016148607 countsByYear W20161486072021 @default.
- W2016148607 countsByYear W20161486072022 @default.
- W2016148607 countsByYear W20161486072023 @default.
- W2016148607 crossrefType "journal-article" @default.
- W2016148607 hasAuthorship W2016148607A5004038379 @default.
- W2016148607 hasAuthorship W2016148607A5007755251 @default.
- W2016148607 hasAuthorship W2016148607A5031060352 @default.
- W2016148607 hasAuthorship W2016148607A5036257218 @default.
- W2016148607 hasAuthorship W2016148607A5042296036 @default.