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- W2016151310 abstract "The study aimed to detect CD8 + CD25 + FoxP3 brigh T regs and investigate their possible association with selected lung function values. CD8 + CD25 + FoxP3 brigh T regs were detected by flow cytometry in the peripheral blood of 25 patients with severe asthma (SA), 25 patients with mild-to-moderate asthma (MA), and 25 age-matched healthy donors (NC). The percentages of CD8 + CD25 + FoxP3 brigh T regs of the patients with severe (3.4 ± 4.55), and mild-to-moderate asthma (7.5 ± 8.15), were markedly lower than those of controls (12.1 ± 13.2). The mean forced expiratory volume in 1 s (FEV 1 ) % predicted value in severe asthma subpopulation was significantly lower (67.05 ± 15.98%) when compared with that of mild-to-moderate asthma subgroup (87.71 ± 16.12%). Interestingly, the percentages of CD8 + CD25 + FoxP3 brigh T regs correlate with mean peak expiratory flow (PEF)% predicted values in severe (r = 0.7, P <0.01) and mild-to-moderate (r = 0.73, P <0.01) asthma. In contrast, this parameter was positively correlated with FEV 1 % predicted values in the severe asthmatics only (r = 0.71, P <0.01). In summary, this study establishes a link between the percentage of CD8 + CD25 + FoxP3 brigh T regs and selected lung function parameters, suggesting that this parameter has potential as a marker for inflammation and airflow obstruction." @default.
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- W2016151310 date "2015-04-28" @default.
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- W2016151310 title "The relative values of CD8<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>brigh</sup> Treg cells correlate with selected lung function parameters in asthma" @default.
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- W2016151310 doi "https://doi.org/10.1177/0394632015584508" @default.
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