Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016160402> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2016160402 endingPage "2106" @default.
- W2016160402 startingPage "2101" @default.
- W2016160402 abstract "This article briefly introduces the results of in silico prediction of the most probable metabolism sites for the human cytochrome P450 3A4 and 2D6 isoforms. Ligand-based QSAR models have been developed using a novel GALAS modeling approach, and provide probabilities of being a target of CYP3A4 or CYP2D6 for any atom in a molecule. The GALAS-model development methodology allows evaluation of the reliability of predictions in the form of estimated prediction Reliability Indices (RIs). For all the models considered in this study, the number of misclassifications and inconclusive results was reduced significantly when only predictions of high quality (RI>0.5) were taken into account, demonstrating that RI reflects accuracy of prediction. The applicability domain of regioselectivity models is shown to be easily expandable to cover compound classes of interest to the user. The results obtained so far show promising perspectives for the utilization of the GALAS modeling in the analysis of regioselectivity for other important biotransformation enzymes--a work currently in progress." @default.
- W2016160402 created "2016-06-24" @default.
- W2016160402 creator A5012501898 @default.
- W2016160402 creator A5078258593 @default.
- W2016160402 creator A5091513476 @default.
- W2016160402 date "2009-11-01" @default.
- W2016160402 modified "2023-09-24" @default.
- W2016160402 title "Probabilistic Prediction of the Human CYP3A4 and CYP2D6 Metabolism Sites" @default.
- W2016160402 cites W1966008148 @default.
- W2016160402 cites W1971223189 @default.
- W2016160402 cites W1992475241 @default.
- W2016160402 cites W1997039157 @default.
- W2016160402 cites W2038344991 @default.
- W2016160402 cites W2052659467 @default.
- W2016160402 cites W2101900366 @default.
- W2016160402 cites W2105587896 @default.
- W2016160402 cites W2106109834 @default.
- W2016160402 cites W2130983257 @default.
- W2016160402 cites W2153467586 @default.
- W2016160402 cites W2175094258 @default.
- W2016160402 doi "https://doi.org/10.1002/cbdv.200900078" @default.
- W2016160402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19937844" @default.
- W2016160402 hasPublicationYear "2009" @default.
- W2016160402 type Work @default.
- W2016160402 sameAs 2016160402 @default.
- W2016160402 citedByCount "13" @default.
- W2016160402 countsByYear W20161604022012 @default.
- W2016160402 countsByYear W20161604022014 @default.
- W2016160402 countsByYear W20161604022015 @default.
- W2016160402 countsByYear W20161604022016 @default.
- W2016160402 countsByYear W20161604022022 @default.
- W2016160402 countsByYear W20161604022023 @default.
- W2016160402 crossrefType "journal-article" @default.
- W2016160402 hasAuthorship W2016160402A5012501898 @default.
- W2016160402 hasAuthorship W2016160402A5078258593 @default.
- W2016160402 hasAuthorship W2016160402A5091513476 @default.
- W2016160402 hasConcept C104317684 @default.
- W2016160402 hasConcept C107908354 @default.
- W2016160402 hasConcept C121332964 @default.
- W2016160402 hasConcept C154945302 @default.
- W2016160402 hasConcept C163258240 @default.
- W2016160402 hasConcept C164126121 @default.
- W2016160402 hasConcept C181199279 @default.
- W2016160402 hasConcept C185592680 @default.
- W2016160402 hasConcept C186060115 @default.
- W2016160402 hasConcept C2775905019 @default.
- W2016160402 hasConcept C41008148 @default.
- W2016160402 hasConcept C43214815 @default.
- W2016160402 hasConcept C49937458 @default.
- W2016160402 hasConcept C526171541 @default.
- W2016160402 hasConcept C55493867 @default.
- W2016160402 hasConcept C70721500 @default.
- W2016160402 hasConcept C71240020 @default.
- W2016160402 hasConcept C86803240 @default.
- W2016160402 hasConcept C97355855 @default.
- W2016160402 hasConceptScore W2016160402C104317684 @default.
- W2016160402 hasConceptScore W2016160402C107908354 @default.
- W2016160402 hasConceptScore W2016160402C121332964 @default.
- W2016160402 hasConceptScore W2016160402C154945302 @default.
- W2016160402 hasConceptScore W2016160402C163258240 @default.
- W2016160402 hasConceptScore W2016160402C164126121 @default.
- W2016160402 hasConceptScore W2016160402C181199279 @default.
- W2016160402 hasConceptScore W2016160402C185592680 @default.
- W2016160402 hasConceptScore W2016160402C186060115 @default.
- W2016160402 hasConceptScore W2016160402C2775905019 @default.
- W2016160402 hasConceptScore W2016160402C41008148 @default.
- W2016160402 hasConceptScore W2016160402C43214815 @default.
- W2016160402 hasConceptScore W2016160402C49937458 @default.
- W2016160402 hasConceptScore W2016160402C526171541 @default.
- W2016160402 hasConceptScore W2016160402C55493867 @default.
- W2016160402 hasConceptScore W2016160402C70721500 @default.
- W2016160402 hasConceptScore W2016160402C71240020 @default.
- W2016160402 hasConceptScore W2016160402C86803240 @default.
- W2016160402 hasConceptScore W2016160402C97355855 @default.
- W2016160402 hasIssue "11" @default.
- W2016160402 hasLocation W20161604021 @default.
- W2016160402 hasLocation W20161604022 @default.
- W2016160402 hasOpenAccess W2016160402 @default.
- W2016160402 hasPrimaryLocation W20161604021 @default.
- W2016160402 hasRelatedWork W2064956914 @default.
- W2016160402 hasRelatedWork W2119723273 @default.
- W2016160402 hasRelatedWork W2153604880 @default.
- W2016160402 hasRelatedWork W2526026918 @default.
- W2016160402 hasRelatedWork W2728144370 @default.
- W2016160402 hasRelatedWork W2766878249 @default.
- W2016160402 hasRelatedWork W2795174043 @default.
- W2016160402 hasRelatedWork W2965192962 @default.
- W2016160402 hasRelatedWork W4210390879 @default.
- W2016160402 hasRelatedWork W4256182355 @default.
- W2016160402 hasVolume "6" @default.
- W2016160402 isParatext "false" @default.
- W2016160402 isRetracted "false" @default.
- W2016160402 magId "2016160402" @default.
- W2016160402 workType "article" @default.