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- W2016162831 endingPage "622" @default.
- W2016162831 startingPage "609" @default.
- W2016162831 abstract "The relationships between insulin, insulin resistance and atherosclerosis are still a matter of intense debate [1±4] even though it was suggested as long as 30 years ago that insulin is involved in the pathogenesis of atherosclerosis [5]. It is not clear whether insulin plays the role of a culprit, an innocent bystander, a factor involved in the attenuation of some steps in the atherogenic process or an agent with multifaceted actions having different and possibly contrasting effects. The question is: is the prevalence of atherosclerosis in the insulin-resistant states due to hyperinsulinaemia or to the presence of cellular resistance to some anti-atherogenic insulin actions? To answer we need to know the mechanisms by which insulin influences the cells involved in the pathogenesis of atherosclerosis. In this review we examine the way in which insulin affects platelet function. Platelets are essential elements in the thrombotic and atherosclerotic processes because of their own functional properties and their ability to interact with endothelial and vascular smooth muscle cells (VSMC) [6]. As VSMC share common features in their contractile structure and its regulation with platelets [7] we also compare the effect of insulin and insulin resistance on these two types of cells. In particular we lay emphasis on the modulation of calcium fluxes, cyclic nucleotide concentrations, nitric oxide and prostacyclin actions." @default.
- W2016162831 created "2016-06-24" @default.
- W2016162831 creator A5041207535 @default.
- W2016162831 creator A5090558283 @default.
- W2016162831 date "1998-05-27" @default.
- W2016162831 modified "2023-09-27" @default.
- W2016162831 title "Insulin, insulin resistance and platelet function: similarities with insulin effects on cultured vascular smooth muscle cells" @default.
- W2016162831 cites W122989367 @default.
- W2016162831 cites W127742586 @default.
- W2016162831 cites W1483105549 @default.
- W2016162831 cites W1505418107 @default.
- W2016162831 cites W1555776210 @default.
- W2016162831 cites W1568982528 @default.
- W2016162831 cites W1572362848 @default.
- W2016162831 cites W1585250500 @default.
- W2016162831 cites W1604493583 @default.
- W2016162831 cites W1605361498 @default.
- W2016162831 cites W1823411753 @default.
- W2016162831 cites W1837479159 @default.
- W2016162831 cites W1875612207 @default.
- W2016162831 cites W1891400074 @default.
- W2016162831 cites W1900029203 @default.
- W2016162831 cites W1929009802 @default.
- W2016162831 cites W194846262 @default.
- W2016162831 cites W1964908624 @default.
- W2016162831 cites W1964962754 @default.
- W2016162831 cites W1966462221 @default.
- W2016162831 cites W1968243691 @default.
- W2016162831 cites W1968579026 @default.
- W2016162831 cites W1968688007 @default.
- W2016162831 cites W1970435627 @default.
- W2016162831 cites W1970688869 @default.
- W2016162831 cites W1971345003 @default.
- W2016162831 cites W1971654302 @default.
- W2016162831 cites W1973511325 @default.
- W2016162831 cites W1973657843 @default.
- W2016162831 cites W1977234303 @default.
- W2016162831 cites W1978495647 @default.
- W2016162831 cites W1978663960 @default.
- W2016162831 cites W1980122571 @default.
- W2016162831 cites W1980673978 @default.
- W2016162831 cites W1981920309 @default.
- W2016162831 cites W1982206230 @default.
- W2016162831 cites W1984303164 @default.
- W2016162831 cites W1984513597 @default.
- W2016162831 cites W1984790504 @default.
- W2016162831 cites W1985475177 @default.
- W2016162831 cites W1985548916 @default.
- W2016162831 cites W1988769029 @default.
- W2016162831 cites W1989444655 @default.
- W2016162831 cites W1992549003 @default.
- W2016162831 cites W1993120546 @default.
- W2016162831 cites W1993616390 @default.
- W2016162831 cites W1994237869 @default.
- W2016162831 cites W1994950364 @default.
- W2016162831 cites W1998821592 @default.
- W2016162831 cites W1999633693 @default.
- W2016162831 cites W2000075945 @default.
- W2016162831 cites W2000169571 @default.
- W2016162831 cites W2001110103 @default.
- W2016162831 cites W2001124978 @default.
- W2016162831 cites W2002569534 @default.
- W2016162831 cites W2002685982 @default.
- W2016162831 cites W2002789331 @default.
- W2016162831 cites W2003634812 @default.
- W2016162831 cites W2003922574 @default.
- W2016162831 cites W2006000123 @default.
- W2016162831 cites W2007737411 @default.
- W2016162831 cites W2010100459 @default.
- W2016162831 cites W2012755089 @default.
- W2016162831 cites W2014666095 @default.
- W2016162831 cites W2015130365 @default.
- W2016162831 cites W2015506378 @default.
- W2016162831 cites W2018307163 @default.
- W2016162831 cites W2018866184 @default.
- W2016162831 cites W2019129193 @default.
- W2016162831 cites W2021185979 @default.
- W2016162831 cites W2021884467 @default.
- W2016162831 cites W2021912019 @default.
- W2016162831 cites W2029134608 @default.
- W2016162831 cites W2029987850 @default.
- W2016162831 cites W2030851349 @default.
- W2016162831 cites W2031250144 @default.
- W2016162831 cites W2033307460 @default.
- W2016162831 cites W2037858963 @default.
- W2016162831 cites W2039928997 @default.
- W2016162831 cites W2039949381 @default.
- W2016162831 cites W2040231821 @default.
- W2016162831 cites W2041917913 @default.
- W2016162831 cites W2044450998 @default.
- W2016162831 cites W2045196210 @default.
- W2016162831 cites W2045594638 @default.
- W2016162831 cites W2048214709 @default.
- W2016162831 cites W2048635427 @default.
- W2016162831 cites W2049926734 @default.
- W2016162831 cites W2050908292 @default.
- W2016162831 cites W2055927029 @default.
- W2016162831 cites W2059379142 @default.