Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016163902> ?p ?o ?g. }
- W2016163902 endingPage "513" @default.
- W2016163902 startingPage "507" @default.
- W2016163902 abstract "We used the isolated working rat model to evaluate the effect of therapeutic concentrations (5–10 μM) of ranolazine on contractile performance, oxygen consumption, irreversible ischemic injury, and sarcoplasmic reticulum (SR) function. Ischemic injury was induced by 30 minutes of global ischemia followed by 120 minutes of Langendorff reperfusion and evaluated on the basis of triphenyltetrazolium chloride staining. SR function was determined on the basis of [3H]-ryanodine binding, the kinetics of calcium-induced calcium release, measured by quick filtration technique, and oxalate-supported calcium uptake. In working hearts, ranolazine significantly reduced oxygen consumption (P = 0.031), in the absence of significant changes in contractile performance, and decreased irreversible ischemic injury (P = 0.011), if administered either before ischemia–reperfusion (25.4% ± 4.7% vs. 42.7% ± 6.0%) or only at the time of reperfusion (20.2% ± 5.2% vs. 43.7% ± 9.9%). In SR experiments, treatment with ranolazine determined a significant reduction in [3H]-ryanodine binding (P = 0.029), because of decreased binding site density (369 ± 9 vs. 405 ± 12 fmol/mg), and in the kinetics of SR calcium release (P = 0.011), whose rate constant was decreased, whereas active calcium uptake was not affected. Ranolazine effectiveness at reperfusion and its ability to module SR calcium release suggest that this drug might be particularly useful to induce cardioprotection during coronary revascularization interventions, although the relevance of the effects on calcium homeostasis remains to be determined." @default.
- W2016163902 created "2016-06-24" @default.
- W2016163902 creator A5006502749 @default.
- W2016163902 creator A5033568656 @default.
- W2016163902 creator A5065994277 @default.
- W2016163902 creator A5073460032 @default.
- W2016163902 date "2014-12-01" @default.
- W2016163902 modified "2023-09-30" @default.
- W2016163902 title "Cardioprotection by Ranolazine in Perfused Rat Heart" @default.
- W2016163902 cites W1477089198 @default.
- W2016163902 cites W1569948360 @default.
- W2016163902 cites W1598538024 @default.
- W2016163902 cites W1963627099 @default.
- W2016163902 cites W1967154518 @default.
- W2016163902 cites W1973583204 @default.
- W2016163902 cites W1978276670 @default.
- W2016163902 cites W1981465069 @default.
- W2016163902 cites W1982702289 @default.
- W2016163902 cites W1992405566 @default.
- W2016163902 cites W2019106858 @default.
- W2016163902 cites W2021524119 @default.
- W2016163902 cites W2025715412 @default.
- W2016163902 cites W2034233911 @default.
- W2016163902 cites W2035700338 @default.
- W2016163902 cites W2037472155 @default.
- W2016163902 cites W2045377209 @default.
- W2016163902 cites W2049390983 @default.
- W2016163902 cites W2050824263 @default.
- W2016163902 cites W2057397894 @default.
- W2016163902 cites W2063954755 @default.
- W2016163902 cites W2064284473 @default.
- W2016163902 cites W2065116798 @default.
- W2016163902 cites W2066766993 @default.
- W2016163902 cites W2074126402 @default.
- W2016163902 cites W2075799443 @default.
- W2016163902 cites W2077223958 @default.
- W2016163902 cites W2087412648 @default.
- W2016163902 cites W2091680032 @default.
- W2016163902 cites W2095062180 @default.
- W2016163902 cites W2098373287 @default.
- W2016163902 cites W2099873623 @default.
- W2016163902 cites W2113652223 @default.
- W2016163902 cites W2148346557 @default.
- W2016163902 cites W2149194212 @default.
- W2016163902 cites W2161826934 @default.
- W2016163902 cites W2167211368 @default.
- W2016163902 cites W72002096 @default.
- W2016163902 doi "https://doi.org/10.1097/fjc.0000000000000144" @default.
- W2016163902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25490416" @default.
- W2016163902 hasPublicationYear "2014" @default.
- W2016163902 type Work @default.
- W2016163902 sameAs 2016163902 @default.
- W2016163902 citedByCount "4" @default.
- W2016163902 countsByYear W20161639022015 @default.
- W2016163902 countsByYear W20161639022016 @default.
- W2016163902 countsByYear W20161639022018 @default.
- W2016163902 crossrefType "journal-article" @default.
- W2016163902 hasAuthorship W2016163902A5006502749 @default.
- W2016163902 hasAuthorship W2016163902A5033568656 @default.
- W2016163902 hasAuthorship W2016163902A5065994277 @default.
- W2016163902 hasAuthorship W2016163902A5073460032 @default.
- W2016163902 hasConcept C113217602 @default.
- W2016163902 hasConcept C126322002 @default.
- W2016163902 hasConcept C134018914 @default.
- W2016163902 hasConcept C164705383 @default.
- W2016163902 hasConcept C185592680 @default.
- W2016163902 hasConcept C2779177932 @default.
- W2016163902 hasConcept C2779676291 @default.
- W2016163902 hasConcept C519063684 @default.
- W2016163902 hasConcept C541997718 @default.
- W2016163902 hasConcept C71924100 @default.
- W2016163902 hasConcept C98274493 @default.
- W2016163902 hasConceptScore W2016163902C113217602 @default.
- W2016163902 hasConceptScore W2016163902C126322002 @default.
- W2016163902 hasConceptScore W2016163902C134018914 @default.
- W2016163902 hasConceptScore W2016163902C164705383 @default.
- W2016163902 hasConceptScore W2016163902C185592680 @default.
- W2016163902 hasConceptScore W2016163902C2779177932 @default.
- W2016163902 hasConceptScore W2016163902C2779676291 @default.
- W2016163902 hasConceptScore W2016163902C519063684 @default.
- W2016163902 hasConceptScore W2016163902C541997718 @default.
- W2016163902 hasConceptScore W2016163902C71924100 @default.
- W2016163902 hasConceptScore W2016163902C98274493 @default.
- W2016163902 hasIssue "6" @default.
- W2016163902 hasLocation W20161639021 @default.
- W2016163902 hasLocation W20161639022 @default.
- W2016163902 hasOpenAccess W2016163902 @default.
- W2016163902 hasPrimaryLocation W20161639021 @default.
- W2016163902 hasRelatedWork W1531601525 @default.
- W2016163902 hasRelatedWork W1886857624 @default.
- W2016163902 hasRelatedWork W2003842308 @default.
- W2016163902 hasRelatedWork W2016163902 @default.
- W2016163902 hasRelatedWork W2064236298 @default.
- W2016163902 hasRelatedWork W2095093072 @default.
- W2016163902 hasRelatedWork W2748952813 @default.
- W2016163902 hasRelatedWork W2899084033 @default.
- W2016163902 hasRelatedWork W2948807893 @default.
- W2016163902 hasRelatedWork W2778153218 @default.