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- W2016166860 abstract "Substantial enhancement of recombinant tissue plasminogen activator (rt-PA) thrombolysis can be achieved with diagnostic frequency ultrasound. Microscopic visualization of human whole-blood clots treated with human fresh frozen plasma (HFFP), rt-PA, and 120-KHz pulsed ultrasound offers a useful method to study the possible mechanisms. Whole human-blood clots were formed inside of glass micropipette (1.7-mm diameter) and placed in a water tank at 37<th>°C. The clot–plasma interface was imaged using an inverted optical microscope. Clots were exposed to HFFP (control), HFFP and rt-PA (0.0945 mg/ml), (sham), or HFFP, rt-PA (0.0945 mg/ml), and 120-KHz pulsed ultrasound (ultrasound treated) for 30 min. Thrombolysis at the clot surface was recorded with a CCD camera and the lytic front was analyzed as a function of time. Images of the clots were analyzed to quantify the overall amount of lysis and compared to a dynamic chemical model of enzymatic degradation in the presence of ultrasound-induced flow. Sham and ultrasound-treated clots showed significant lysis with the lytic rate of (1.33±0.02 microns/min; mean ± s.d.) and (5.17±0.10 microns/min), respectively. Ultrasound enhanced thrombolysis by a factor of 4. In addition, the lytic rate profile may offer a suggestion to the mechanism of enhancement. No thrombolysis was observed in control clots. [The authors of this study gratefully acknowledge the support of the Whitaker Foundation Grant RG-0128-01.]" @default.
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- W2016166860 modified "2023-09-27" @default.
- W2016166860 title "In vitro microscopic imaging of rt‐PA thrombolysis with 120‐KHz ultrasound in a human clot model" @default.
- W2016166860 doi "https://doi.org/10.1121/1.4783310" @default.
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