FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016172865> ?p ?o ?g. }

• W2016172865 endingPage "220" @default.
• W2016172865 startingPage "213" @default.
• W2016172865 abstract "The effects of pituitary adenylate cyclase activating polypeptide (PACAP) on the cardiovascular system were examined. When PACAP-38 (270 or 420 pmol/kg body weight) was administered intravenously to the anesthetized dogs, both mean arterial pressure and left ventricular systolic pressure increased within 2 min after a temporal depression. Pulmonary arterial systolic pressure increased promptly. These hemodynamic values and heart rates (HR) 5 min after injection were significantly higher than the corresponding values in physiological saline injected dogs, and some effects were still sustained over 15 min. Cardiac output and stroke volume also increased and the values at 5 min were significantly higher than those in controls. The high dose of PACAP-38 (420 pmol/kg) evoked greater responses than those induced by the low dose (270 pmol/kg). Plasma adrenaline, but neither noradrenaline nor dopamine concentration significantly increased 15 min after injection of 420 pmol/kg PACAP-38. Moreover, PACAP-38 clearly stimulated cyclic AMP production in rat cardiac myocytes with EC50 of 1.5 x 10(-9) M and plasma cAMP levels significantly and dose-dependently increased in dogs 5 min after administration. These results first demonstrated that PACAP has inotropic and chronotropic actions on the heart possibly by a direct stimulation of adenylate cyclase in cardiac myocytes and also that the cardiovascular functions may be possibly modified by an evoked adrenaline secretion in vivo." @default.
• W2016172865 created "2016-06-24" @default.
• W2016172865 creator A5010330520 @default.
• W2016172865 creator A5024101482 @default.
• W2016172865 creator A5030509095 @default.
• W2016172865 creator A5030896432 @default.
• W2016172865 creator A5037205650 @default.
• W2016172865 creator A5045166593 @default.
• W2016172865 creator A5048761504 @default.
• W2016172865 creator A5062310589 @default.
• W2016172865 creator A5083046011 @default.
• W2016172865 date "1993-09-01" @default.
• W2016172865 modified "2023-10-16" @default.
• W2016172865 title "Effects of pituitary adenylate cyclase activating polypeptide (PACAP) on the cardiovascular system" @default.
• W2016172865 cites W1981423842 @default.
• W2016172865 cites W1983600193 @default.
• W2016172865 cites W1985262137 @default.
• W2016172865 cites W1990856194 @default.
• W2016172865 cites W1992104129 @default.
• W2016172865 cites W2001439970 @default.
• W2016172865 cites W2013013487 @default.
• W2016172865 cites W2024948700 @default.
• W2016172865 cites W2033650768 @default.
• W2016172865 cites W2047523044 @default.
• W2016172865 cites W2048528031 @default.
• W2016172865 cites W2059971303 @default.
• W2016172865 cites W2088503917 @default.
• W2016172865 cites W2143055603 @default.
• W2016172865 cites W2410663017 @default.
• W2016172865 cites W2419110058 @default.
• W2016172865 cites W4230571467 @default.
• W2016172865 doi "https://doi.org/10.1016/0167-0115(93)90426-9" @default.
• W2016172865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7901874" @default.
• W2016172865 hasPublicationYear "1993" @default.
• W2016172865 type Work @default.
• W2016172865 sameAs 2016172865 @default.
• W2016172865 citedByCount "22" @default.
• W2016172865 countsByYear W20161728652014 @default.
• W2016172865 countsByYear W20161728652019 @default.
• W2016172865 countsByYear W20161728652023 @default.
• W2016172865 crossrefType "journal-article" @default.
• W2016172865 hasAuthorship W2016172865A5010330520 @default.
• W2016172865 hasAuthorship W2016172865A5024101482 @default.
• W2016172865 hasAuthorship W2016172865A5030509095 @default.
• W2016172865 hasAuthorship W2016172865A5030896432 @default.
• W2016172865 hasAuthorship W2016172865A5037205650 @default.
• W2016172865 hasAuthorship W2016172865A5045166593 @default.
• W2016172865 hasAuthorship W2016172865A5048761504 @default.
• W2016172865 hasAuthorship W2016172865A5062310589 @default.
• W2016172865 hasAuthorship W2016172865A5083046011 @default.
• W2016172865 hasConcept C118303440 @default.
• W2016172865 hasConcept C126322002 @default.
• W2016172865 hasConcept C134018914 @default.
• W2016172865 hasConcept C139940330 @default.
• W2016172865 hasConcept C155710745 @default.
• W2016172865 hasConcept C158328960 @default.
• W2016172865 hasConcept C170493617 @default.
• W2016172865 hasConcept C178853913 @default.
• W2016172865 hasConcept C185592680 @default.
• W2016172865 hasConcept C24998067 @default.
• W2016172865 hasConcept C2777397205 @default.
• W2016172865 hasConcept C2777953023 @default.
• W2016172865 hasConcept C2779496938 @default.
• W2016172865 hasConcept C71924100 @default.
• W2016172865 hasConcept C80461066 @default.
• W2016172865 hasConcept C8330315 @default.
• W2016172865 hasConcept C84393581 @default.
• W2016172865 hasConceptScore W2016172865C118303440 @default.
• W2016172865 hasConceptScore W2016172865C126322002 @default.
• W2016172865 hasConceptScore W2016172865C134018914 @default.
• W2016172865 hasConceptScore W2016172865C139940330 @default.
• W2016172865 hasConceptScore W2016172865C155710745 @default.
• W2016172865 hasConceptScore W2016172865C158328960 @default.
• W2016172865 hasConceptScore W2016172865C170493617 @default.
• W2016172865 hasConceptScore W2016172865C178853913 @default.
• W2016172865 hasConceptScore W2016172865C185592680 @default.
• W2016172865 hasConceptScore W2016172865C24998067 @default.
• W2016172865 hasConceptScore W2016172865C2777397205 @default.
• W2016172865 hasConceptScore W2016172865C2777953023 @default.
• W2016172865 hasConceptScore W2016172865C2779496938 @default.
• W2016172865 hasConceptScore W2016172865C71924100 @default.
• W2016172865 hasConceptScore W2016172865C80461066 @default.
• W2016172865 hasConceptScore W2016172865C8330315 @default.
• W2016172865 hasConceptScore W2016172865C84393581 @default.
• W2016172865 hasIssue "2" @default.
• W2016172865 hasLocation W20161728651 @default.
• W2016172865 hasLocation W20161728652 @default.
• W2016172865 hasOpenAccess W2016172865 @default.
• W2016172865 hasPrimaryLocation W20161728651 @default.
• W2016172865 hasRelatedWork W1968077253 @default.
• W2016172865 hasRelatedWork W2023375677 @default.
• W2016172865 hasRelatedWork W2078774753 @default.
• W2016172865 hasRelatedWork W2091348181 @default.
• W2016172865 hasRelatedWork W2126629559 @default.
• W2016172865 hasRelatedWork W2157068474 @default.
• W2016172865 hasRelatedWork W2412260976 @default.
• W2016172865 hasRelatedWork W2417967658 @default.
• W2016172865 hasRelatedWork W2748952813 @default.

• next