FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016176503> ?p ?o ?g. }

• W2016176503 endingPage "743" @default.
• W2016176503 startingPage "736" @default.
• W2016176503 abstract "We have examined whether expression of angiotensin II (Ang II) type 1 (AT₁) and/or type 2 (AT₂) receptors are changed in thoracic aorta under pressure-overload by abdominal aortic banding in rats and determined whether their changes are accompanied by alteration in contractile response of thoracic aorta to Ang II. AT₂ receptor mRNA levels determined by reverse transcription-polymerase chain reaction or quantitative real-time polymerase chain reaction were increased by about 300% in aortas 4, 7, 14, and 28 days after banding without changes in AT₁ receptor mRNA levels. Contractile response of aortic rings to Ang II was decreased in thoracic aortas 7 days after banding, and AT₂ receptor antagonist PD123319 (1-[[4-(dimethulamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1<i>H</i>-imidazo[4,5-<i>c</i>]pyridine-6-carboxylic acid ditrifluoroacetate) (10^–6 M) increased the Ang II responsiveness in pressure-loaded but not in sham rings. After removal of the endothelium or treatment with <i>N</i>^G-nitro-l-arginine methyl ester (l-NAME), no differences were observed in Ang II responsiveness between sham and pressure-loaded rings. Either losartan (1 mg/kg/day i.p.) or candesartan (2 mg/kg/day p.o.) for 7 days after banding not only abolished the up-regulation of AT₂ receptor mRNA in aortas but also recovered their Ang II responsiveness. Basal cGMP levels were 2 times higher in pressure-loaded than in sham rings; both levels were not affected by Ang II (10^–7 M; 5 min), but greatly decreased by l-NAME (10^–4 M, 30 min). These results suggest that pressure-overload induces the up-regulation of AT₂ receptor expression in aortas via AT₁ receptor and thereby negatively modulates the vasoconstrictor sensitivity to Ang II, probably mediated by the mechanisms independent of the nitric oxide-cGMP system." @default.
• W2016176503 created "2016-06-24" @default.
• W2016176503 creator A5001188770 @default.
• W2016176503 creator A5003825373 @default.
• W2016176503 creator A5004340484 @default.
• W2016176503 creator A5018833836 @default.
• W2016176503 creator A5048277468 @default.
• W2016176503 creator A5073811962 @default.
• W2016176503 creator A5079005439 @default.
• W2016176503 date "2003-11-10" @default.
• W2016176503 modified "2023-10-11" @default.
• W2016176503 title "Up-Regulation of Angiotensin II Type 2 Receptor in Rat Thoracic Aorta by Pressure-Overload" @default.
• W2016176503 cites W1591556642 @default.
• W2016176503 cites W1811210869 @default.
• W2016176503 cites W1967345870 @default.
• W2016176503 cites W1990257506 @default.
• W2016176503 cites W2002717483 @default.
• W2016176503 cites W2013690237 @default.
• W2016176503 cites W2020815929 @default.
• W2016176503 cites W2025098274 @default.
• W2016176503 cites W2030557752 @default.
• W2016176503 cites W2057185378 @default.
• W2016176503 cites W2058755393 @default.
• W2016176503 cites W2060177780 @default.
• W2016176503 cites W2062940490 @default.
• W2016176503 cites W2063360581 @default.
• W2016176503 cites W2082542825 @default.
• W2016176503 cites W2082837211 @default.
• W2016176503 cites W2084130233 @default.
• W2016176503 cites W2094201582 @default.
• W2016176503 cites W2097489256 @default.
• W2016176503 cites W2098291803 @default.
• W2016176503 cites W2104950980 @default.
• W2016176503 cites W2118700340 @default.
• W2016176503 cites W2149429779 @default.
• W2016176503 cites W2149743327 @default.
• W2016176503 cites W2161595178 @default.
• W2016176503 cites W2166343963 @default.
• W2016176503 cites W2170047585 @default.
• W2016176503 cites W1967473058 @default.
• W2016176503 doi "https://doi.org/10.1124/jpet.103.058420" @default.
• W2016176503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14610239" @default.
• W2016176503 hasPublicationYear "2003" @default.
• W2016176503 type Work @default.
• W2016176503 sameAs 2016176503 @default.
• W2016176503 citedByCount "63" @default.
• W2016176503 countsByYear W20161765032012 @default.
• W2016176503 countsByYear W20161765032013 @default.
• W2016176503 countsByYear W20161765032014 @default.
• W2016176503 countsByYear W20161765032015 @default.
• W2016176503 countsByYear W20161765032016 @default.
• W2016176503 countsByYear W20161765032017 @default.
• W2016176503 countsByYear W20161765032018 @default.
• W2016176503 countsByYear W20161765032020 @default.
• W2016176503 countsByYear W20161765032021 @default.
• W2016176503 countsByYear W20161765032022 @default.
• W2016176503 countsByYear W20161765032023 @default.
• W2016176503 crossrefType "journal-article" @default.
• W2016176503 hasAuthorship W2016176503A5001188770 @default.
• W2016176503 hasAuthorship W2016176503A5003825373 @default.
• W2016176503 hasAuthorship W2016176503A5004340484 @default.
• W2016176503 hasAuthorship W2016176503A5018833836 @default.
• W2016176503 hasAuthorship W2016176503A5048277468 @default.
• W2016176503 hasAuthorship W2016176503A5073811962 @default.
• W2016176503 hasAuthorship W2016176503A5079005439 @default.
• W2016176503 hasConcept C126322002 @default.
• W2016176503 hasConcept C134018914 @default.
• W2016176503 hasConcept C170493617 @default.
• W2016176503 hasConcept C185592680 @default.
• W2016176503 hasConcept C198710026 @default.
• W2016176503 hasConcept C2776864027 @default.
• W2016176503 hasConcept C2776885963 @default.
• W2016176503 hasConcept C2778122271 @default.
• W2016176503 hasConcept C2779980429 @default.
• W2016176503 hasConcept C2780288358 @default.
• W2016176503 hasConcept C2908929049 @default.
• W2016176503 hasConcept C71924100 @default.
• W2016176503 hasConcept C84393581 @default.
• W2016176503 hasConcept C86803240 @default.
• W2016176503 hasConceptScore W2016176503C126322002 @default.
• W2016176503 hasConceptScore W2016176503C134018914 @default.
• W2016176503 hasConceptScore W2016176503C170493617 @default.
• W2016176503 hasConceptScore W2016176503C185592680 @default.
• W2016176503 hasConceptScore W2016176503C198710026 @default.
• W2016176503 hasConceptScore W2016176503C2776864027 @default.
• W2016176503 hasConceptScore W2016176503C2776885963 @default.
• W2016176503 hasConceptScore W2016176503C2778122271 @default.
• W2016176503 hasConceptScore W2016176503C2779980429 @default.
• W2016176503 hasConceptScore W2016176503C2780288358 @default.
• W2016176503 hasConceptScore W2016176503C2908929049 @default.
• W2016176503 hasConceptScore W2016176503C71924100 @default.
• W2016176503 hasConceptScore W2016176503C84393581 @default.
• W2016176503 hasConceptScore W2016176503C86803240 @default.
• W2016176503 hasIssue "2" @default.
• W2016176503 hasLocation W20161765031 @default.
• W2016176503 hasLocation W20161765032 @default.
• W2016176503 hasOpenAccess W2016176503 @default.
• W2016176503 hasPrimaryLocation W20161765031 @default.

• next