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- W2016176990 abstract "During Bombyx mori follicle development, fine-tuning of chorion gene expression is under the control of bidirectional promoters. In this work, we show that the silkmoth chromo-helicase/ATPase-DNA binding protein 1 (CHD1) ortholog is responsible for repositioning of nucleosomes on chorion promoters, where the factor binds specifically. Chorion genes, occupying a single chromosomal locus, rely on an almost identical set of cis elements for their differential expression. As a direct consequence of remodeling, interaction of C/EBP and TFIID with promoter elements is facilitated and ultimately leads to initiation of transcription. Appending of methylation marks to H3K4 in a temporal-specific manner is dependent on CHD1 binding to cognate cis elements and signifies gene activation. Overall, CHD1 is a critical factor for proper development of the follicular epithelium in terms of whole-cell chromatin arrangement." @default.
- W2016176990 created "2016-06-24" @default.
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- W2016176990 date "2008-11-01" @default.
- W2016176990 modified "2023-09-26" @default.
- W2016176990 title "CHD1 Assumes a Central Role during Follicle Development" @default.
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- W2016176990 doi "https://doi.org/10.1016/j.jmb.2008.09.011" @default.
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