FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016178777> ?p ?o ?g. }

• W2016178777 endingPage "67" @default.
• W2016178777 startingPage "63" @default.
• W2016178777 abstract "India has the greatest number of diabetic subjects in any one country, but the genetic basis of type 2 diabetes mellitus in India is poorly understood. Common non-coding variants in the transcription factor 7-like 2 gene (TCF7L2) have recently been strongly associated with increased risk of type 2 diabetes in European populations. We investigated whether TCF7L2 variants are also associated with type 2 diabetes mellitus in the Indian population.We genotyped type 2 diabetes patients (n = 955) and ethnically matched control subjects (n = 399) by sequencing three single nucleotide polymorphisms (SNPs) (rs7903146, rs12255372 and rs4506565) in TCF7L2.We observed a strong association with all the polymorphisms, including rs12255372 (odds ratio [OR] 1.50 [95% CI = 1.24-1.82], p = 4.0 x 10(-5)), rs4506565 (OR 1.48 [95% CI = 1.24-1.77], p = 2.0 x 10(-5)) and rs7903146 (OR 1.46 [95% CI = 1.22-1.75], p = 3.0 x 10(-5)). All three variants showed increased relative risk when homozygous rather than heterozygous, with the strongest risk for rs12255372 (OR 2.28 [95% CI = 1.40-3.72] vs OR 1.43 [95% CI = 1.11-1.83]). We found no association of the TCF7L2 genotypes with age at diagnosis, BMI or WHR, but the risk genotype at rs12255372 was associated with higher fasting plasma glucose (p = 0.001), higher 2-h plasma glucose (p = 0.0002) and higher homeostasis model assessment of insulin resistance (HOMA-R; p = 0.012) in non-diabetic subjects.Our study in Indian subjects replicates the strong association of TCF7L2 variants with type 2 diabetes in other populations. It also provides evidence that variations in TCF7L2 may play a crucial role in the pathogenesis of type 2 diabetes by influencing both insulin secretion and insulin resistance. TCF7L2 is an important gene for determining susceptibility to type 2 diabetes mellitus and it transgresses the boundaries of ethnicity." @default.
• W2016178777 created "2016-06-24" @default.
• W2016178777 creator A5028009201 @default.
• W2016178777 creator A5032422723 @default.
• W2016178777 creator A5035049718 @default.
• W2016178777 creator A5039598016 @default.
• W2016178777 creator A5052307736 @default.
• W2016178777 creator A5069686473 @default.
• W2016178777 creator A5069878997 @default.
• W2016178777 creator A5070850677 @default.
• W2016178777 date "2006-11-09" @default.
• W2016178777 modified "2023-09-30" @default.
• W2016178777 title "Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population" @default.
• W2016178777 cites W1485161311 @default.
• W2016178777 cites W1965141016 @default.
• W2016178777 cites W2021029274 @default.
• W2016178777 cites W2021425141 @default.
• W2016178777 cites W2039403622 @default.
• W2016178777 cites W2077464018 @default.
• W2016178777 cites W2078408147 @default.
• W2016178777 cites W2090430326 @default.
• W2016178777 cites W2138695913 @default.
• W2016178777 cites W2149524485 @default.
• W2016178777 cites W2152326504 @default.
• W2016178777 cites W2169174186 @default.
• W2016178777 doi "https://doi.org/10.1007/s00125-006-0502-2" @default.
• W2016178777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17093941" @default.
• W2016178777 hasPublicationYear "2006" @default.
• W2016178777 type Work @default.
• W2016178777 sameAs 2016178777 @default.
• W2016178777 citedByCount "237" @default.
• W2016178777 countsByYear W20161787772012 @default.
• W2016178777 countsByYear W20161787772013 @default.
• W2016178777 countsByYear W20161787772014 @default.
• W2016178777 countsByYear W20161787772015 @default.
• W2016178777 countsByYear W20161787772016 @default.
• W2016178777 countsByYear W20161787772017 @default.
• W2016178777 countsByYear W20161787772018 @default.
• W2016178777 countsByYear W20161787772019 @default.
• W2016178777 countsByYear W20161787772020 @default.
• W2016178777 countsByYear W20161787772021 @default.
• W2016178777 countsByYear W20161787772022 @default.
• W2016178777 countsByYear W20161787772023 @default.
• W2016178777 crossrefType "journal-article" @default.
• W2016178777 hasAuthorship W2016178777A5028009201 @default.
• W2016178777 hasAuthorship W2016178777A5032422723 @default.
• W2016178777 hasAuthorship W2016178777A5035049718 @default.
• W2016178777 hasAuthorship W2016178777A5039598016 @default.
• W2016178777 hasAuthorship W2016178777A5052307736 @default.
• W2016178777 hasAuthorship W2016178777A5069686473 @default.
• W2016178777 hasAuthorship W2016178777A5069878997 @default.
• W2016178777 hasAuthorship W2016178777A5070850677 @default.
• W2016178777 hasBestOaLocation W20161787771 @default.
• W2016178777 hasConcept C104317684 @default.
• W2016178777 hasConcept C126322002 @default.
• W2016178777 hasConcept C134018914 @default.
• W2016178777 hasConcept C135763542 @default.
• W2016178777 hasConcept C153209595 @default.
• W2016178777 hasConcept C156957248 @default.
• W2016178777 hasConcept C2777180221 @default.
• W2016178777 hasConcept C2777391703 @default.
• W2016178777 hasConcept C2908647359 @default.
• W2016178777 hasConcept C2910068830 @default.
• W2016178777 hasConcept C39263347 @default.
• W2016178777 hasConcept C54355233 @default.
• W2016178777 hasConcept C555293320 @default.
• W2016178777 hasConcept C71924100 @default.
• W2016178777 hasConcept C86803240 @default.
• W2016178777 hasConcept C99454951 @default.
• W2016178777 hasConceptScore W2016178777C104317684 @default.
• W2016178777 hasConceptScore W2016178777C126322002 @default.
• W2016178777 hasConceptScore W2016178777C134018914 @default.
• W2016178777 hasConceptScore W2016178777C135763542 @default.
• W2016178777 hasConceptScore W2016178777C153209595 @default.
• W2016178777 hasConceptScore W2016178777C156957248 @default.
• W2016178777 hasConceptScore W2016178777C2777180221 @default.
• W2016178777 hasConceptScore W2016178777C2777391703 @default.
• W2016178777 hasConceptScore W2016178777C2908647359 @default.
• W2016178777 hasConceptScore W2016178777C2910068830 @default.
• W2016178777 hasConceptScore W2016178777C39263347 @default.
• W2016178777 hasConceptScore W2016178777C54355233 @default.
• W2016178777 hasConceptScore W2016178777C555293320 @default.
• W2016178777 hasConceptScore W2016178777C71924100 @default.
• W2016178777 hasConceptScore W2016178777C86803240 @default.
• W2016178777 hasConceptScore W2016178777C99454951 @default.
• W2016178777 hasIssue "1" @default.
• W2016178777 hasLocation W20161787771 @default.
• W2016178777 hasLocation W20161787772 @default.
• W2016178777 hasOpenAccess W2016178777 @default.
• W2016178777 hasPrimaryLocation W20161787771 @default.
• W2016178777 hasRelatedWork W1979252938 @default.
• W2016178777 hasRelatedWork W2032225465 @default.
• W2016178777 hasRelatedWork W2044823377 @default.
• W2016178777 hasRelatedWork W2169206971 @default.
• W2016178777 hasRelatedWork W2378290744 @default.
• W2016178777 hasRelatedWork W2391899759 @default.
• W2016178777 hasRelatedWork W2584731720 @default.
• W2016178777 hasRelatedWork W2886303208 @default.

• next