FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016179633> ?p ?o ?g. }

• W2016179633 endingPage "207" @default.
• W2016179633 startingPage "199" @default.
• W2016179633 abstract "<b><i>Background:</i></b> Apoptosis is recognized as an important mechanism in contrast-induced nephropathy (CIN). As tetramethylpyrazine (TMP) has been recently found to be renoprotective and anti-apoptotic in multiple kidney injuries, we hypothesized that TMP would prevent CIN. <b><i>Methods:</i></b> An experimental model of CIN was established in rats. Serum creatinine, blood urea nitrogen, plasma cystatin C, urinary N-acetyl-β-glucosaminidase, and urinary &#947;-glutamyl transpeptidase were measured to evaluate kidney function. Apoptosis was assessed by transmission electron microscopy, transferase-mediated deoxyuridine triphosphate nick end-labeling staining, and poly-ADP-ribose polymerase cleavage. Fork-head box O1 transcriptional factor (FoxO1) mRNA expression was evaluated by quantitative real-time PCR. Phospho-p38 mitogen-activated protein kinase (MAPK) protein expression was assessed by immunohistochemistry and Western blotting. <b><i>Results:</i></b> TMP significantly attenuated the resulting renal dysfunction and renal tubular cell apo-ptosis. Mechanistically, TMP decreased the expression of phospho-p38 MAPK protein and attenuated the increased FoxO1 mRNA and nuclear protein expression. In addition, TMP inhibited inducible nitric oxide synthase and Bax protein expression while it upregulated Bcl-2. <b><i>Conclusion:</i></b> In summary, this study demonstrated the protective role of TMP against CIN and indicated the effects of TMP may be mediated by the inhibition of p38 MAPK and FoxO1 pathways. Thus, TMP may be a new potential therapeutic agent to prevent CIN." @default.
• W2016179633 created "2016-06-24" @default.
• W2016179633 creator A5001207267 @default.
• W2016179633 creator A5011942982 @default.
• W2016179633 creator A5024962900 @default.
• W2016179633 creator A5046225712 @default.
• W2016179633 creator A5051792379 @default.
• W2016179633 creator A5057714592 @default.
• W2016179633 creator A5072983863 @default.
• W2016179633 creator A5091870178 @default.
• W2016179633 date "2013-01-01" @default.
• W2016179633 modified "2023-09-24" @default.
• W2016179633 title "Tetramethylpyrazine Prevents Contrast-Induced Nephropathy by Inhibiting p38 MAPK and FoxO1 Signaling Pathways" @default.
• W2016179633 cites W1975568780 @default.
• W2016179633 cites W1979268981 @default.
• W2016179633 cites W1986362009 @default.
• W2016179633 cites W1990406110 @default.
• W2016179633 cites W1992920273 @default.
• W2016179633 cites W1993223474 @default.
• W2016179633 cites W2011944584 @default.
• W2016179633 cites W2025914616 @default.
• W2016179633 cites W2030351477 @default.
• W2016179633 cites W2033637369 @default.
• W2016179633 cites W2037544714 @default.
• W2016179633 cites W2060150397 @default.
• W2016179633 cites W2070919564 @default.
• W2016179633 cites W2084485916 @default.
• W2016179633 cites W2095708294 @default.
• W2016179633 cites W2105952878 @default.
• W2016179633 cites W2125097752 @default.
• W2016179633 cites W2130976170 @default.
• W2016179633 cites W2133303352 @default.
• W2016179633 cites W2143222346 @default.
• W2016179633 cites W2151894362 @default.
• W2016179633 cites W2165041545 @default.
• W2016179633 cites W2166103710 @default.
• W2016179633 cites W2196822239 @default.
• W2016179633 doi "https://doi.org/10.1159/000347033" @default.
• W2016179633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23446291" @default.
• W2016179633 hasPublicationYear "2013" @default.
• W2016179633 type Work @default.
• W2016179633 sameAs 2016179633 @default.
• W2016179633 citedByCount "29" @default.
• W2016179633 countsByYear W20161796332014 @default.
• W2016179633 countsByYear W20161796332015 @default.
• W2016179633 countsByYear W20161796332016 @default.
• W2016179633 countsByYear W20161796332017 @default.
• W2016179633 countsByYear W20161796332019 @default.
• W2016179633 countsByYear W20161796332020 @default.
• W2016179633 countsByYear W20161796332021 @default.
• W2016179633 countsByYear W20161796332022 @default.
• W2016179633 countsByYear W20161796332023 @default.
• W2016179633 crossrefType "journal-article" @default.
• W2016179633 hasAuthorship W2016179633A5001207267 @default.
• W2016179633 hasAuthorship W2016179633A5011942982 @default.
• W2016179633 hasAuthorship W2016179633A5024962900 @default.
• W2016179633 hasAuthorship W2016179633A5046225712 @default.
• W2016179633 hasAuthorship W2016179633A5051792379 @default.
• W2016179633 hasAuthorship W2016179633A5057714592 @default.
• W2016179633 hasAuthorship W2016179633A5072983863 @default.
• W2016179633 hasAuthorship W2016179633A5091870178 @default.
• W2016179633 hasConcept C126322002 @default.
• W2016179633 hasConcept C134018914 @default.
• W2016179633 hasConcept C140149449 @default.
• W2016179633 hasConcept C142724271 @default.
• W2016179633 hasConcept C153911025 @default.
• W2016179633 hasConcept C181199279 @default.
• W2016179633 hasConcept C182979987 @default.
• W2016179633 hasConcept C184235292 @default.
• W2016179633 hasConcept C185592680 @default.
• W2016179633 hasConcept C190283241 @default.
• W2016179633 hasConcept C204787440 @default.
• W2016179633 hasConcept C2778176769 @default.
• W2016179633 hasConcept C2778208062 @default.
• W2016179633 hasConcept C2779138821 @default.
• W2016179633 hasConcept C2779548226 @default.
• W2016179633 hasConcept C2780091579 @default.
• W2016179633 hasConcept C2780306776 @default.
• W2016179633 hasConcept C51551487 @default.
• W2016179633 hasConcept C55493867 @default.
• W2016179633 hasConcept C57074206 @default.
• W2016179633 hasConcept C71924100 @default.
• W2016179633 hasConcept C75217442 @default.
• W2016179633 hasConcept C82381507 @default.
• W2016179633 hasConcept C86803240 @default.
• W2016179633 hasConceptScore W2016179633C126322002 @default.
• W2016179633 hasConceptScore W2016179633C134018914 @default.
• W2016179633 hasConceptScore W2016179633C140149449 @default.
• W2016179633 hasConceptScore W2016179633C142724271 @default.
• W2016179633 hasConceptScore W2016179633C153911025 @default.
• W2016179633 hasConceptScore W2016179633C181199279 @default.
• W2016179633 hasConceptScore W2016179633C182979987 @default.
• W2016179633 hasConceptScore W2016179633C184235292 @default.
• W2016179633 hasConceptScore W2016179633C185592680 @default.
• W2016179633 hasConceptScore W2016179633C190283241 @default.
• W2016179633 hasConceptScore W2016179633C204787440 @default.
• W2016179633 hasConceptScore W2016179633C2778176769 @default.
• W2016179633 hasConceptScore W2016179633C2778208062 @default.

• next