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• W2016181650 endingPage "467" @default.
• W2016181650 startingPage "461" @default.
• W2016181650 abstract "Antigen processing is the conversion of native antigen molecules into short peptides that can then bind to major histocompatibility complex (MHC) molecules. Class II MHC (MHC-II) molecules target to endocytic compartments, where they bind peptides that are produced by internalization of extracellular antigens and subsequent antigen catabolism. The resulting peptide-MHC complexes are displayed on the surface of antigen-presenting cells for recognition by T cells. Thus, MHC-II molecules first serve as peptide receptors that rescue peptides from total lysosomal degradation and transport them to the plasma membrane; the MHC-II molecules then form a composite peptide-MHC-II determinant that is recognized by the T cell receptor. Recent work has begun to clarify the molecular events and transport mechanisms that govern antigen processing." @default.
• W2016181650 created "2016-06-24" @default.
• W2016181650 creator A5055729386 @default.
• W2016181650 date "1993-05-01" @default.
• W2016181650 modified "2023-09-27" @default.
• W2016181650 title "Cellular and Molecular Aspects of Antigen Processing and the Function of Class II MHC Molecules" @default.
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• W2016181650 doi "https://doi.org/10.1165/ajrcmb/8.5.461" @default.
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