Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016185123> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2016185123 endingPage "1838" @default.
- W2016185123 startingPage "1829" @default.
- W2016185123 abstract "Oral dosage forms and traditional transdermal patches are inadequate for complex clonidine therapy dosing schemes, because of the variable dose/flux requirement for the treatment of opioid withdrawal symptoms. The purpose of this study was to evaluate the in vitro transdermal flux changes of clonidine in response to alterations in carbon nanotube (CNT) delivery rates by applying various electrical bias. Additional skin diffusion studies were carried out to demonstrate the therapeutic feasibility of the system. This study demonstrated that application of a small electrical bias (-600 mV) to the CNT membrane on the skin resulted in a 4.7-fold increase in clonidine flux as compared with no bias (0 mV) application. The high and low clonidine flux values were very close to the desired variable flux of clonidine for the treatment of opioid withdrawal symptoms. Therapeutic feasibility studies demonstrated that CNT membrane served as the rate-limiting step to clonidine diffusion and lag and transition times were suitable for the clonidine therapy. Skin elimination studies revealed that clonidine depletion from the skin would not negatively affect clonidine therapy. Overall, this study showed that clonidine administration difficulties associated with the treatment of opiate withdrawal symptoms can be reduced with the programmable CNT membrane transdermal system. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:1829-1838, 2014" @default.
- W2016185123 created "2016-06-24" @default.
- W2016185123 creator A5006318211 @default.
- W2016185123 creator A5011866169 @default.
- W2016185123 creator A5015188579 @default.
- W2016185123 creator A5015194042 @default.
- W2016185123 creator A5028652380 @default.
- W2016185123 creator A5032840111 @default.
- W2016185123 creator A5081043831 @default.
- W2016185123 date "2014-06-01" @default.
- W2016185123 modified "2023-10-16" @default.
- W2016185123 title "Programmable Transdermal Clonidine Delivery Through Voltage-Gated Carbon Nanotube Membranes" @default.
- W2016185123 cites W1568798952 @default.
- W2016185123 cites W1965696184 @default.
- W2016185123 cites W1969823428 @default.
- W2016185123 cites W1970051466 @default.
- W2016185123 cites W1979084995 @default.
- W2016185123 cites W1984207232 @default.
- W2016185123 cites W1990155238 @default.
- W2016185123 cites W1998222388 @default.
- W2016185123 cites W2004764447 @default.
- W2016185123 cites W2016181184 @default.
- W2016185123 cites W2021626201 @default.
- W2016185123 cites W2040121807 @default.
- W2016185123 cites W2067121767 @default.
- W2016185123 cites W2068122687 @default.
- W2016185123 cites W2093874526 @default.
- W2016185123 cites W2108379938 @default.
- W2016185123 cites W2135549485 @default.
- W2016185123 cites W2136290763 @default.
- W2016185123 cites W2139459152 @default.
- W2016185123 cites W2144678438 @default.
- W2016185123 cites W2769182252 @default.
- W2016185123 cites W4254997096 @default.
- W2016185123 doi "https://doi.org/10.1002/jps.23940" @default.
- W2016185123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4218846" @default.
- W2016185123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24788096" @default.
- W2016185123 hasPublicationYear "2014" @default.
- W2016185123 type Work @default.
- W2016185123 sameAs 2016185123 @default.
- W2016185123 citedByCount "9" @default.
- W2016185123 countsByYear W20161851232015 @default.
- W2016185123 countsByYear W20161851232016 @default.
- W2016185123 countsByYear W20161851232017 @default.
- W2016185123 countsByYear W20161851232019 @default.
- W2016185123 countsByYear W20161851232020 @default.
- W2016185123 countsByYear W20161851232022 @default.
- W2016185123 crossrefType "journal-article" @default.
- W2016185123 hasAuthorship W2016185123A5006318211 @default.
- W2016185123 hasAuthorship W2016185123A5011866169 @default.
- W2016185123 hasAuthorship W2016185123A5015188579 @default.
- W2016185123 hasAuthorship W2016185123A5015194042 @default.
- W2016185123 hasAuthorship W2016185123A5028652380 @default.
- W2016185123 hasAuthorship W2016185123A5032840111 @default.
- W2016185123 hasAuthorship W2016185123A5081043831 @default.
- W2016185123 hasBestOaLocation W20161851232 @default.
- W2016185123 hasConcept C205679159 @default.
- W2016185123 hasConcept C2778399450 @default.
- W2016185123 hasConcept C42219234 @default.
- W2016185123 hasConcept C71924100 @default.
- W2016185123 hasConcept C98274493 @default.
- W2016185123 hasConceptScore W2016185123C205679159 @default.
- W2016185123 hasConceptScore W2016185123C2778399450 @default.
- W2016185123 hasConceptScore W2016185123C42219234 @default.
- W2016185123 hasConceptScore W2016185123C71924100 @default.
- W2016185123 hasConceptScore W2016185123C98274493 @default.
- W2016185123 hasIssue "6" @default.
- W2016185123 hasLocation W20161851231 @default.
- W2016185123 hasLocation W20161851232 @default.
- W2016185123 hasLocation W20161851233 @default.
- W2016185123 hasLocation W20161851234 @default.
- W2016185123 hasOpenAccess W2016185123 @default.
- W2016185123 hasPrimaryLocation W20161851231 @default.
- W2016185123 hasRelatedWork W170156493 @default.
- W2016185123 hasRelatedWork W1985830405 @default.
- W2016185123 hasRelatedWork W2016185123 @default.
- W2016185123 hasRelatedWork W2017945832 @default.
- W2016185123 hasRelatedWork W2095016438 @default.
- W2016185123 hasRelatedWork W2316615694 @default.
- W2016185123 hasRelatedWork W3100520806 @default.
- W2016185123 hasRelatedWork W3102103028 @default.
- W2016185123 hasRelatedWork W4249875466 @default.
- W2016185123 hasRelatedWork W4256452679 @default.
- W2016185123 hasVolume "103" @default.
- W2016185123 isParatext "false" @default.
- W2016185123 isRetracted "false" @default.
- W2016185123 magId "2016185123" @default.
- W2016185123 workType "article" @default.