FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016190015> ?p ?o ?g. }

• W2016190015 endingPage "859" @default.
• W2016190015 startingPage "851" @default.
• W2016190015 abstract "OnabotulinumtoxinA was effective and well tolerated for prophylaxis of headache in patients with chronic migraine (CM) in two randomized, double-blind, placebo-controlled, phase 3 trials. To further assess the safety and tolerability of onabotulinumtoxinA in CM prophylaxis in adults, the pooled safety data from four double-blind, placebo-controlled trials were analyzed.The pooled analysis included two phase 2 and two phase 3 double-blind, placebo-controlled trials. The safety population was 2436 patients, 1997 of whom received ≥1 dose of onabotulinumtoxinA. The studies shared similar dosing intervals (approximately 12 weeks) with doses between 75 and 260 U. Safety assessments included adverse events (AEs), physical examination and clinical laboratory tests.OnabotulinumtoxinA was safe and well tolerated, with a low discontinuation rate (3.4%) due to AEs. The majority of patients in this pooled analysis received doses between 150 and 200 U, with an average of 163 U per treatment cycle. Of the 1997 patients who received any onabotulinumtoxinA injections, 1455 patients (72.9%) reported at least one AE. Neck pain (12.6%) was the most common onabotulinumtoxinA-associated AE, followed by muscle weakness (8.0%), musculoskeletal stiffness (6.1%) and eyelid ptosis (4.6%). Serious AEs were infrequent, occurring in 5.4% of patients who received any onabotulinumtoxinA treatment and 3.0% of patients receiving placebo. AEs were consistent with the known tolerability profile of onabotulinumtoxinA.Multiple treatments with onabotulinumtoxinA at doses of 75-260 U administered every 12 weeks, and up to five treatment cycles, were well tolerated for the prophylaxis of headache in adults with CM." @default.
• W2016190015 created "2016-06-24" @default.
• W2016190015 creator A5003434565 @default.
• W2016190015 creator A5013719819 @default.
• W2016190015 creator A5049158075 @default.
• W2016190015 creator A5057290642 @default.
• W2016190015 creator A5078582922 @default.
• W2016190015 creator A5088972033 @default.
• W2016190015 creator A5090882838 @default.
• W2016190015 date "2014-03-15" @default.
• W2016190015 modified "2023-09-27" @default.
• W2016190015 title "Pooled analysis of the safety and tolerability of onabotulinumtoxinA in the treatment of chronic migraine" @default.
• W2016190015 cites W1984095842 @default.
• W2016190015 cites W1994481205 @default.
• W2016190015 cites W2007410119 @default.
• W2016190015 cites W2022807726 @default.
• W2016190015 cites W2023557896 @default.
• W2016190015 cites W2048499176 @default.
• W2016190015 cites W2066871405 @default.
• W2016190015 cites W2080945262 @default.
• W2016190015 cites W2084866959 @default.
• W2016190015 cites W2110018721 @default.
• W2016190015 cites W2115337076 @default.
• W2016190015 cites W2118912931 @default.
• W2016190015 cites W2121437343 @default.
• W2016190015 cites W2127042724 @default.
• W2016190015 cites W2134001075 @default.
• W2016190015 cites W2160202859 @default.
• W2016190015 cites W2162210794 @default.
• W2016190015 cites W2167719770 @default.
• W2016190015 cites W2170860462 @default.
• W2016190015 cites W2769724041 @default.
• W2016190015 cites W3022218734 @default.
• W2016190015 cites W4230120862 @default.
• W2016190015 doi "https://doi.org/10.1111/ene.12393" @default.
• W2016190015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4233954" @default.
• W2016190015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24628923" @default.
• W2016190015 hasPublicationYear "2014" @default.
• W2016190015 type Work @default.
• W2016190015 sameAs 2016190015 @default.
• W2016190015 citedByCount "47" @default.
• W2016190015 countsByYear W20161900152014 @default.
• W2016190015 countsByYear W20161900152015 @default.
• W2016190015 countsByYear W20161900152016 @default.
• W2016190015 countsByYear W20161900152017 @default.
• W2016190015 countsByYear W20161900152018 @default.
• W2016190015 countsByYear W20161900152019 @default.
• W2016190015 countsByYear W20161900152020 @default.
• W2016190015 countsByYear W20161900152021 @default.
• W2016190015 countsByYear W20161900152022 @default.
• W2016190015 countsByYear W20161900152023 @default.
• W2016190015 crossrefType "journal-article" @default.
• W2016190015 hasAuthorship W2016190015A5003434565 @default.
• W2016190015 hasAuthorship W2016190015A5013719819 @default.
• W2016190015 hasAuthorship W2016190015A5049158075 @default.
• W2016190015 hasAuthorship W2016190015A5057290642 @default.
• W2016190015 hasAuthorship W2016190015A5078582922 @default.
• W2016190015 hasAuthorship W2016190015A5088972033 @default.
• W2016190015 hasAuthorship W2016190015A5090882838 @default.
• W2016190015 hasBestOaLocation W20161900151 @default.
• W2016190015 hasConcept C126322002 @default.
• W2016190015 hasConcept C141071460 @default.
• W2016190015 hasConcept C142724271 @default.
• W2016190015 hasConcept C197934379 @default.
• W2016190015 hasConcept C204787440 @default.
• W2016190015 hasConcept C27081682 @default.
• W2016190015 hasConcept C2777288759 @default.
• W2016190015 hasConcept C2778375690 @default.
• W2016190015 hasConcept C2778541695 @default.
• W2016190015 hasConcept C2778715236 @default.
• W2016190015 hasConcept C2908647359 @default.
• W2016190015 hasConcept C42219234 @default.
• W2016190015 hasConcept C71924100 @default.
• W2016190015 hasConcept C99454951 @default.
• W2016190015 hasConceptScore W2016190015C126322002 @default.
• W2016190015 hasConceptScore W2016190015C141071460 @default.
• W2016190015 hasConceptScore W2016190015C142724271 @default.
• W2016190015 hasConceptScore W2016190015C197934379 @default.
• W2016190015 hasConceptScore W2016190015C204787440 @default.
• W2016190015 hasConceptScore W2016190015C27081682 @default.
• W2016190015 hasConceptScore W2016190015C2777288759 @default.
• W2016190015 hasConceptScore W2016190015C2778375690 @default.
• W2016190015 hasConceptScore W2016190015C2778541695 @default.
• W2016190015 hasConceptScore W2016190015C2778715236 @default.
• W2016190015 hasConceptScore W2016190015C2908647359 @default.
• W2016190015 hasConceptScore W2016190015C42219234 @default.
• W2016190015 hasConceptScore W2016190015C71924100 @default.
• W2016190015 hasConceptScore W2016190015C99454951 @default.
• W2016190015 hasIssue "6" @default.
• W2016190015 hasLocation W20161900151 @default.
• W2016190015 hasLocation W20161900152 @default.
• W2016190015 hasLocation W20161900153 @default.
• W2016190015 hasLocation W20161900154 @default.
• W2016190015 hasOpenAccess W2016190015 @default.
• W2016190015 hasPrimaryLocation W20161900151 @default.
• W2016190015 hasRelatedWork W1550475500 @default.
• W2016190015 hasRelatedWork W17603917 @default.
• W2016190015 hasRelatedWork W2022556905 @default.

• next