FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016191004> ?p ?o ?g. }

• W2016191004 endingPage "177" @default.
• W2016191004 startingPage "169" @default.
• W2016191004 abstract "The aim of this study was to evaluate the use of cationic–hydrophilic copolymers for self-assembly with antisense oligonucleotides targeted to the bcl-2 mRNA in order to improve their biocompatibility and modulation of their pharmacokinetics for greater therapeutic usefulness. Examination of the ability of poly(trimethylammonioethyl methacrylate chloride)–poly[N-(2-hydroxypropyl)methacrylamide] (pHPMA-b-pTMAEM) block copolymers to condense the oligonucleotide by fluorescence and electrophoresis techniques showed that complexes were formed more efficiently than with copolymers containing poly(ethylene glycol) blocks grafted onto the backbone of poly(l-lysine) (pLL-g-pEG). In addition, the copolymer pTMAEM-b-pHPMA produced oligonucleotide complexes with the most favourable physicochemical properties appropriate for in vivo applications. The complexes were small (approximately 36 nm in diameter), with low surface charge as measured by zeta potential, relatively stable to physiological salt conditions and could be formed at a DNA concentration of 500 μg/ml. Complex formation with the copolymer pTMAEM-b-pHPMA or pLL-g-pEG reduced the urinary clearance of the oligonucleotide after intravenous injection into mice. However after 30 min, the oligonucleotide complexes were cleared from the bloodstream. These results indicate that for the systemic delivery of oligonucleotides the polymer-derived complexes are not stable enough for prolonged circulation. Instead, these complexes may be more suitable for localised in vivo applications." @default.
• W2016191004 created "2016-06-24" @default.
• W2016191004 creator A5006838317 @default.
• W2016191004 creator A5016187749 @default.
• W2016191004 creator A5024571471 @default.
• W2016191004 creator A5027016284 @default.
• W2016191004 creator A5032131181 @default.
• W2016191004 creator A5040270800 @default.
• W2016191004 creator A5046402449 @default.
• W2016191004 creator A5049524766 @default.
• W2016191004 creator A5061536944 @default.
• W2016191004 creator A5065948625 @default.
• W2016191004 date "2000-05-01" @default.
• W2016191004 modified "2023-10-04" @default.
• W2016191004 title "Physicochemical and biological characterisation of an antisense oligonucleotide targeted against the bcl-2 mRNA complexed with cationic–hydrophilic copolymers" @default.
• W2016191004 cites W1580329779 @default.
• W2016191004 cites W1594288804 @default.
• W2016191004 cites W1821878109 @default.
• W2016191004 cites W1982632260 @default.
• W2016191004 cites W1988771401 @default.
• W2016191004 cites W1996701312 @default.
• W2016191004 cites W2000161442 @default.
• W2016191004 cites W2008243768 @default.
• W2016191004 cites W2008327280 @default.
• W2016191004 cites W2009328461 @default.
• W2016191004 cites W2013156289 @default.
• W2016191004 cites W2020223696 @default.
• W2016191004 cites W2024256121 @default.
• W2016191004 cites W2036242475 @default.
• W2016191004 cites W2062358875 @default.
• W2016191004 cites W2064580002 @default.
• W2016191004 cites W2067855092 @default.
• W2016191004 cites W2074254849 @default.
• W2016191004 cites W2074870430 @default.
• W2016191004 cites W2078447684 @default.
• W2016191004 cites W2082617049 @default.
• W2016191004 cites W2093007266 @default.
• W2016191004 cites W2118137379 @default.
• W2016191004 cites W2135368384 @default.
• W2016191004 cites W2151766851 @default.
• W2016191004 cites W2346338657 @default.
• W2016191004 doi "https://doi.org/10.1016/s0928-0987(00)00069-5" @default.
• W2016191004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10767594" @default.
• W2016191004 hasPublicationYear "2000" @default.
• W2016191004 type Work @default.
• W2016191004 sameAs 2016191004 @default.
• W2016191004 citedByCount "22" @default.
• W2016191004 countsByYear W20161910042012 @default.
• W2016191004 countsByYear W20161910042014 @default.
• W2016191004 countsByYear W20161910042015 @default.
• W2016191004 countsByYear W20161910042016 @default.
• W2016191004 crossrefType "journal-article" @default.
• W2016191004 hasAuthorship W2016191004A5006838317 @default.
• W2016191004 hasAuthorship W2016191004A5016187749 @default.
• W2016191004 hasAuthorship W2016191004A5024571471 @default.
• W2016191004 hasAuthorship W2016191004A5027016284 @default.
• W2016191004 hasAuthorship W2016191004A5032131181 @default.
• W2016191004 hasAuthorship W2016191004A5040270800 @default.
• W2016191004 hasAuthorship W2016191004A5046402449 @default.
• W2016191004 hasAuthorship W2016191004A5049524766 @default.
• W2016191004 hasAuthorship W2016191004A5061536944 @default.
• W2016191004 hasAuthorship W2016191004A5065948625 @default.
• W2016191004 hasConcept C10138342 @default.
• W2016191004 hasConcept C12554922 @default.
• W2016191004 hasConcept C129312508 @default.
• W2016191004 hasConcept C150903083 @default.
• W2016191004 hasConcept C15920480 @default.
• W2016191004 hasConcept C162324750 @default.
• W2016191004 hasConcept C178790620 @default.
• W2016191004 hasConcept C183882617 @default.
• W2016191004 hasConcept C185592680 @default.
• W2016191004 hasConcept C188027245 @default.
• W2016191004 hasConcept C207001950 @default.
• W2016191004 hasConcept C2775961978 @default.
• W2016191004 hasConcept C2777230088 @default.
• W2016191004 hasConcept C2777516009 @default.
• W2016191004 hasConcept C2779402116 @default.
• W2016191004 hasConcept C521977710 @default.
• W2016191004 hasConcept C54400483 @default.
• W2016191004 hasConcept C552990157 @default.
• W2016191004 hasConcept C55493867 @default.
• W2016191004 hasConcept C86803240 @default.
• W2016191004 hasConceptScore W2016191004C10138342 @default.
• W2016191004 hasConceptScore W2016191004C12554922 @default.
• W2016191004 hasConceptScore W2016191004C129312508 @default.
• W2016191004 hasConceptScore W2016191004C150903083 @default.
• W2016191004 hasConceptScore W2016191004C15920480 @default.
• W2016191004 hasConceptScore W2016191004C162324750 @default.
• W2016191004 hasConceptScore W2016191004C178790620 @default.
• W2016191004 hasConceptScore W2016191004C183882617 @default.
• W2016191004 hasConceptScore W2016191004C185592680 @default.
• W2016191004 hasConceptScore W2016191004C188027245 @default.
• W2016191004 hasConceptScore W2016191004C207001950 @default.
• W2016191004 hasConceptScore W2016191004C2775961978 @default.
• W2016191004 hasConceptScore W2016191004C2777230088 @default.
• W2016191004 hasConceptScore W2016191004C2777516009 @default.
• W2016191004 hasConceptScore W2016191004C2779402116 @default.
• W2016191004 hasConceptScore W2016191004C521977710 @default.

• next