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- W2016191229 abstract "Plasma cholesterol levels, plasma lactate, and total body RQ were measured in septic patients undergoing total parenteral nutrition (TPN) with glucose, fat, and two different branch-chain amino acid admixtures (49% BCAA and 16% BCAA). Mean plasma cholesterol for all measurements (2.61 ± 0.94 [SD] mmol/L) was lower than normal; however, it was higher with 49% BCAA than with 16% BCAA (2.94 ± 0.95 vs. 2.27 ± 0.81 mmol/L, p < .001) for comparable loads of glucose, fat, and total amino acids. Plasma lactate and RQ were lower with 49% BCAA than with 16% BCAA (p < .001 for both). Cholesterol was directly related to the absolute dose of BCAA (p < .001), was unrelated to the dose of non-BCAA, and was inversely related to lactate (p < .001). These results suggest that BCAA ketoacids contribute to cholesterol synthesis in sepsis, as well as being an oxidative source. The data also suggest that the reduction in alanine in BCAA-enriched amino-acid TPN assists in the lowering of plasma lactate secondary to abnormal septic glucose metabolism." @default.
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- W2016191229 date "1990-01-01" @default.
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- W2016191229 title "Relationship of plasma cholesterol level to doses of branch-chain amino acids in sepsis" @default.
- W2016191229 doi "https://doi.org/10.1097/00003246-199001000-00009" @default.
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