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- W2016194209 abstract "Uptake and cell nuclear binding of [3H]corticosterone was studied in 300 μm slices of brain regions of adrenalectomized rats. (1) Slice uptake of radioactivity was linear as a function of hormone concentration, while nuclear binding was saturated at2 × 10−8 M [3H]corticosterone. Once bound to nuclei, [3H]corticosterone could not be displaced by1 × 10−5 M corticosterone during a 30 min incubation at 25 °C. (2) Nuclear binding was optimal at 25 °C. Decreased binding at 0 °C was not due to limitations of cellular energy production, as shown in experiments with metabolic inhibitors. (3) Nuclear binding was highest in hippocampus, followed by amygdala, cerebral cortex, hypothalamus-preoptic area, midbrain, and cerebellum. Thesein vitro results agree with the regional distribution of binding obtained in previousin vivo labeling experiments. (4) [3H]Corticosterone binds better to hippocampal nuclei than [3H]hydrocortisone, while [3H]progesterone does not bind to nuclei. Unlabeled corticosterone and, to a lesser extent, both hydrocortisone and progesterone all prevent nuclear binding of [3H]corticosterone. (5) The soluble brain corticosterone-binding protein (Kaat0 °C4.2 × 108 M−1) does bind [3H]progesterone as well as [3H]corticosterone and [3H]hydrocortisone, and unlabeled progesterone prevents binding of [3H]corticosterone to this protein. It is suggested that, in binding to the cytosol protein, progesterone prevents nuclear accumulation of [3H]corticosterone, and the likelihood of cytosol to nuclear transfer of hormone is discussed. (6) The soluble brain corticosterone-binding protein is shown to differ from serum corticosterone-binding protein by binding dexamethasone and having sulfhydryl groups essential for hormone binding." @default.
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- W2016194209 title "Corticosterone binding to hippocampus: nuclear and cytosol bindingin vitro" @default.
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- W2016194209 doi "https://doi.org/10.1016/0006-8993(73)90143-1" @default.
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