Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016195427> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2016195427 endingPage "1808" @default.
- W2016195427 startingPage "1804" @default.
- W2016195427 abstract "During ontogeny IgD appears later than IgM on splenocytes of neonatal mice (1) and at a time when mice develop a markedly increased immune responsiveness (2). Based on these observations, it was suggested that IgD serves as a triggering isotype for induction of immune responses, whereas surface IgM functions as a tolerizing receptor (3). To test this hypothesis, the susceptibility of adult splenocytes (which are predominantly μ(+)δ(+)[4-6]) and neonatal splenocytes (which bear predominantly IgM [μp(+); 1, 4-6]) to tolerance induction were compared. The results indicate that neonatal splenic B cells responsive to thymus dependent (TD) antigens are exquisitely susceptible to tolerance induction compared with those from adult mice (7-9). However, cells from both adult and neonatal mice were highly susceptible to tolerance induction when thymus independent (TI) antigen was used as immunogen (8). These results suggest that the major precursor for the TD response is a μ(+)δ(+)-cell which appears late in ontogeny and is resistant to tolerance induction and that the μp(+)-cell is the major precursor for the TI response and is highly susceptible to tolerance induction. Other differences between responders for TI and TD antigens have been described previously (10-12). To test this concept, adult splenocytes were treated with papain under conditions in which IgD, but not five other surface molecules, was removed (13). Such treated splenocytes were shown to be markedly susceptible to tolerance induction, resembling TD responders from neonatal animals. This experiment was interpreted as indicating that IgD confers resistance to tolerance induction on μ(+)δ(+)-cells. To prove this interpretation, it is necessary to show that specific removal of IgD with anti-δ also results in increased susceptibility to tolerance induction and that treatment with anti-μ does not have a similar effect. In the present studies, we have removed surface IgM or IgD by antibody-induced capping and assessed the tolerance susceptibility of the treated cells. Our results demonstrate that removal of IgD, but no IgM, from TD responders increases their susceptibility to tolerance induction." @default.
- W2016195427 created "2016-06-24" @default.
- W2016195427 creator A5001194184 @default.
- W2016195427 creator A5025107178 @default.
- W2016195427 creator A5063233755 @default.
- W2016195427 creator A5064429049 @default.
- W2016195427 creator A5084475433 @default.
- W2016195427 date "1977-12-01" @default.
- W2016195427 modified "2023-09-24" @default.
- W2016195427 title "B-cell tolerance. IV. Differential role of surface IgM and IgD in determining tolerance susceptibility of murine B cells" @default.
- W2016195427 cites W1966270194 @default.
- W2016195427 cites W2007686427 @default.
- W2016195427 cites W2020724587 @default.
- W2016195427 cites W2021294068 @default.
- W2016195427 cites W2023186710 @default.
- W2016195427 cites W2026389397 @default.
- W2016195427 cites W2050356435 @default.
- W2016195427 cites W2052733766 @default.
- W2016195427 cites W2055187407 @default.
- W2016195427 cites W2062177195 @default.
- W2016195427 cites W2077194449 @default.
- W2016195427 cites W2097686001 @default.
- W2016195427 cites W2100076275 @default.
- W2016195427 cites W2136102813 @default.
- W2016195427 cites W2153616900 @default.
- W2016195427 cites W2418246362 @default.
- W2016195427 cites W4247053457 @default.
- W2016195427 doi "https://doi.org/10.1084/jem.146.6.1804" @default.
- W2016195427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2181918" @default.
- W2016195427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/303688" @default.
- W2016195427 hasPublicationYear "1977" @default.
- W2016195427 type Work @default.
- W2016195427 sameAs 2016195427 @default.
- W2016195427 citedByCount "74" @default.
- W2016195427 countsByYear W20161954272016 @default.
- W2016195427 countsByYear W20161954272018 @default.
- W2016195427 crossrefType "journal-article" @default.
- W2016195427 hasAuthorship W2016195427A5001194184 @default.
- W2016195427 hasAuthorship W2016195427A5025107178 @default.
- W2016195427 hasAuthorship W2016195427A5063233755 @default.
- W2016195427 hasAuthorship W2016195427A5064429049 @default.
- W2016195427 hasAuthorship W2016195427A5084475433 @default.
- W2016195427 hasBestOaLocation W20161954272 @default.
- W2016195427 hasConcept C147483822 @default.
- W2016195427 hasConcept C159654299 @default.
- W2016195427 hasConcept C189976730 @default.
- W2016195427 hasConcept C203014093 @default.
- W2016195427 hasConcept C2776090121 @default.
- W2016195427 hasConcept C2777702733 @default.
- W2016195427 hasConcept C2778453870 @default.
- W2016195427 hasConcept C2779909307 @default.
- W2016195427 hasConcept C48010095 @default.
- W2016195427 hasConcept C542903549 @default.
- W2016195427 hasConcept C86803240 @default.
- W2016195427 hasConcept C8891405 @default.
- W2016195427 hasConceptScore W2016195427C147483822 @default.
- W2016195427 hasConceptScore W2016195427C159654299 @default.
- W2016195427 hasConceptScore W2016195427C189976730 @default.
- W2016195427 hasConceptScore W2016195427C203014093 @default.
- W2016195427 hasConceptScore W2016195427C2776090121 @default.
- W2016195427 hasConceptScore W2016195427C2777702733 @default.
- W2016195427 hasConceptScore W2016195427C2778453870 @default.
- W2016195427 hasConceptScore W2016195427C2779909307 @default.
- W2016195427 hasConceptScore W2016195427C48010095 @default.
- W2016195427 hasConceptScore W2016195427C542903549 @default.
- W2016195427 hasConceptScore W2016195427C86803240 @default.
- W2016195427 hasConceptScore W2016195427C8891405 @default.
- W2016195427 hasIssue "6" @default.
- W2016195427 hasLocation W20161954271 @default.
- W2016195427 hasLocation W20161954272 @default.
- W2016195427 hasLocation W20161954273 @default.
- W2016195427 hasLocation W20161954274 @default.
- W2016195427 hasOpenAccess W2016195427 @default.
- W2016195427 hasPrimaryLocation W20161954271 @default.
- W2016195427 hasRelatedWork W1564188261 @default.
- W2016195427 hasRelatedWork W2002073873 @default.
- W2016195427 hasRelatedWork W2016195427 @default.
- W2016195427 hasRelatedWork W2150920263 @default.
- W2016195427 hasRelatedWork W2391198628 @default.
- W2016195427 hasRelatedWork W3021967600 @default.
- W2016195427 hasRelatedWork W402048087 @default.
- W2016195427 hasRelatedWork W4313359200 @default.
- W2016195427 hasRelatedWork W4313386283 @default.
- W2016195427 hasRelatedWork W70067030 @default.
- W2016195427 hasVolume "146" @default.
- W2016195427 isParatext "false" @default.
- W2016195427 isRetracted "false" @default.
- W2016195427 magId "2016195427" @default.
- W2016195427 workType "article" @default.