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• W2016200596 abstract "Abstract We have previously shown that synthetic archaeal lipid analogues are useful vectors for drug/gene delivery. We report herein the synthesis and gene transfer properties of a series of novel di‐ and tetraether‐type archaeal derivatives with a poly(ethylene glycol) (PEG) chain and further equipped with a folic acid (FA) group. The synthetic strategy and the purification by dialysis ensured complete removal of free FA. The lipids were mixed with a conventional glycine betaine‐based cationic lipid and the resulting formulations were tested in transfection assays after complexation with plasmid DNA. All four novel co‐lipids afforded efficient in vitro gene transfection. Moreover, the FA‐equipped derivatives permitted ligand/receptor‐based targeted transfection; their activity was inhibited when free FA was added to the transfection medium. These novel archaeal derivatives equipped with FA‐PEG moieties may thus be of great interest for targeted in vivo transfection." @default.
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• W2016200596 date "2008-09-15" @default.
• W2016200596 modified "2023-10-18" @default.
• W2016200596 title "Folate-Equipped Pegylated Archaeal Lipid Derivatives: Synthesis and Transfection Properties" @default.
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• W2016200596 doi "https://doi.org/10.1002/chem.200800950" @default.
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