Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016203213> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2016203213 endingPage "2359" @default.
- W2016203213 startingPage "2354" @default.
- W2016203213 abstract "CD28 is a T cell surface molecule that is important for T cell activation. CD28-triggered T cell stimulation involves protein tyrosine phosphorylation, a process that is critical for CD28 function. Recently, a linker molecule has been identified as LAT (Linker for Activation of T cells). Studies involving LAT mutants and reconstitution experiments strongly implicate LAT in playing a critical role in T cell activation. We show in the present report that CD28 ligation induces tyrosine phosphorylation of LAT. CD28-induced tyrosine phosphorylation of LAT was rapid, as it was apparent within 1 min of CD28 ligation, reached a peak by 5 min, and declined thereafter. Previous studies implicated the protein tyrosine kinases ZAP-70 and Syk in the TCR-induced tyrosine phosphorylation of LAT. Here, tyrosine phosphorylation of Syk and ZAP-70 was detected after TCR but not after CD28 ligation. Thus, CD28 ligation appears to induce tyrosine phosphorylation of LAT by mechanisms that are independent of ZAP-70 and Syk. The concurrent ligation of CD28 and TCR increased tyrosine phosphorylation of LAT. These results implicate LAT in CD28 signal transduction pathways and in the co-stimulatory process in T cells." @default.
- W2016203213 created "2016-06-24" @default.
- W2016203213 creator A5000305032 @default.
- W2016203213 creator A5016394693 @default.
- W2016203213 creator A5041151171 @default.
- W2016203213 creator A5046190031 @default.
- W2016203213 date "1999-07-01" @default.
- W2016203213 modified "2023-09-26" @default.
- W2016203213 title "CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation" @default.
- W2016203213 cites W108215184 @default.
- W2016203213 cites W1804861156 @default.
- W2016203213 cites W1990311250 @default.
- W2016203213 cites W2004668797 @default.
- W2016203213 cites W2022594276 @default.
- W2016203213 cites W2027541502 @default.
- W2016203213 cites W2032523932 @default.
- W2016203213 cites W2043007190 @default.
- W2016203213 cites W2050031403 @default.
- W2016203213 cites W2054083392 @default.
- W2016203213 cites W2062059331 @default.
- W2016203213 cites W2070673941 @default.
- W2016203213 cites W2073580811 @default.
- W2016203213 cites W2077888296 @default.
- W2016203213 cites W2083984611 @default.
- W2016203213 cites W2088525733 @default.
- W2016203213 cites W2090481553 @default.
- W2016203213 cites W2091783976 @default.
- W2016203213 cites W2092109378 @default.
- W2016203213 cites W2092312916 @default.
- W2016203213 cites W2111844459 @default.
- W2016203213 cites W2125314411 @default.
- W2016203213 doi "https://doi.org/10.1002/(sici)1521-4141(199907)29:07<2354::aid-immu2354>3.0.co;2-p" @default.
- W2016203213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10427998" @default.
- W2016203213 hasPublicationYear "1999" @default.
- W2016203213 type Work @default.
- W2016203213 sameAs 2016203213 @default.
- W2016203213 citedByCount "25" @default.
- W2016203213 countsByYear W20162032132012 @default.
- W2016203213 countsByYear W20162032132018 @default.
- W2016203213 crossrefType "journal-article" @default.
- W2016203213 hasAuthorship W2016203213A5000305032 @default.
- W2016203213 hasAuthorship W2016203213A5016394693 @default.
- W2016203213 hasAuthorship W2016203213A5041151171 @default.
- W2016203213 hasAuthorship W2016203213A5046190031 @default.
- W2016203213 hasConcept C11960822 @default.
- W2016203213 hasConcept C148125776 @default.
- W2016203213 hasConcept C153911025 @default.
- W2016203213 hasConcept C197153747 @default.
- W2016203213 hasConcept C203014093 @default.
- W2016203213 hasConcept C2776090121 @default.
- W2016203213 hasConcept C2776165026 @default.
- W2016203213 hasConcept C2777553839 @default.
- W2016203213 hasConcept C35174551 @default.
- W2016203213 hasConcept C42362537 @default.
- W2016203213 hasConcept C55493867 @default.
- W2016203213 hasConcept C62478195 @default.
- W2016203213 hasConcept C86803240 @default.
- W2016203213 hasConcept C8891405 @default.
- W2016203213 hasConcept C95444343 @default.
- W2016203213 hasConceptScore W2016203213C11960822 @default.
- W2016203213 hasConceptScore W2016203213C148125776 @default.
- W2016203213 hasConceptScore W2016203213C153911025 @default.
- W2016203213 hasConceptScore W2016203213C197153747 @default.
- W2016203213 hasConceptScore W2016203213C203014093 @default.
- W2016203213 hasConceptScore W2016203213C2776090121 @default.
- W2016203213 hasConceptScore W2016203213C2776165026 @default.
- W2016203213 hasConceptScore W2016203213C2777553839 @default.
- W2016203213 hasConceptScore W2016203213C35174551 @default.
- W2016203213 hasConceptScore W2016203213C42362537 @default.
- W2016203213 hasConceptScore W2016203213C55493867 @default.
- W2016203213 hasConceptScore W2016203213C62478195 @default.
- W2016203213 hasConceptScore W2016203213C86803240 @default.
- W2016203213 hasConceptScore W2016203213C8891405 @default.
- W2016203213 hasConceptScore W2016203213C95444343 @default.
- W2016203213 hasIssue "7" @default.
- W2016203213 hasLocation W20162032131 @default.
- W2016203213 hasLocation W20162032132 @default.
- W2016203213 hasOpenAccess W2016203213 @default.
- W2016203213 hasPrimaryLocation W20162032131 @default.
- W2016203213 hasRelatedWork W1886292263 @default.
- W2016203213 hasRelatedWork W2016203213 @default.
- W2016203213 hasRelatedWork W2030277142 @default.
- W2016203213 hasRelatedWork W2090863009 @default.
- W2016203213 hasRelatedWork W2130802705 @default.
- W2016203213 hasRelatedWork W2166126152 @default.
- W2016203213 hasRelatedWork W2767338046 @default.
- W2016203213 hasRelatedWork W3172183594 @default.
- W2016203213 hasRelatedWork W4242103831 @default.
- W2016203213 hasRelatedWork W4313368740 @default.
- W2016203213 hasVolume "29" @default.
- W2016203213 isParatext "false" @default.
- W2016203213 isRetracted "false" @default.
- W2016203213 magId "2016203213" @default.
- W2016203213 workType "article" @default.