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- W2016203304 abstract "A rapid and accurate liquid chromatographic method is described for the simultaneous determination of roxithromycin and ambroxol hydrochloride in a new tablet formulation. Chromatographic separation of the two drugs was achieved on a Diamonsil™ C18 column (200mm×4.6 mm, 5 μm). The mobile phase consisting of a mixture of acetonitrile, methanol and 0.5% ammonium acetate (39:11:50 (v/v), pH 5.5) was delivered at a flow rate of 1.0 ml/min. Detection was performed at 220 nm. Linearity, accuracy and precision were found to be acceptable over the concentration range of 201.2–2012.0 μg/ml for roxithromycin and 42.7–427.0 μg/ml for ambroxol hydrochloride, respectively. Separation was complete in less than 10 min. The proposed method can be used for the quality control of formulation products." @default.
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- W2016203304 date "2004-09-01" @default.
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- W2016203304 title "Simultaneous determination of roxithromycin and ambroxol hydrochloride in a new tablet formulation by liquid chromatography" @default.
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- W2016203304 doi "https://doi.org/10.1016/j.jpba.2004.04.001" @default.
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