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- W2016204660 abstract "This study investigated the pharmacological treatment of delusional depressives by assigning patients on a random double-blind basis to amitriptyline (AT) alone, perphenazine (PER) alone, or AT + PER. As reported in an earlier paper, the combination of AT + PER was the superior treatment with a response rate of 78% compared with 41% for AT alone and 19% for PER alone. This difference is both clinically and statistically significant (p < 0.01). In this second article, the authors report that the patients on AT + PER had higher plasma levels of AT and its pharmacologically active metabolite nortriptyline (NT) than the patients on AT alone. Although the response rate had a direct relationship to AT + NT plasma levels, an analysis of variance showed that the group of patients treated with AT + PER still had a significantly higher response rate, even after controlling for the plasma levels of AT + NT (p < 0.05). There was also a correlation between PER plasma levels and clinical response." @default.
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- W2016204660 date "1986-12-01" @default.
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- W2016204660 title "The Pharmacological Treatment of Delusional Depression" @default.
- W2016204660 doi "https://doi.org/10.1097/00004714-198612000-00003" @default.
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