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• W2016205531 endingPage "375" @default.
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• W2016205531 abstract "Quantitative receptor autoradiography was used to examine the sequential patterns of changes in dopaminergic and glutamatergic receptors in the brain of rats lesioned with 6-hydroxydopamine. The animals were unilaterally lesioned in the medial forebrain bundle and the brains were analyzed at 1, 2, 4 and 8 weeks of postlesion. Degeneration of the nigrostriatal pathway caused a significant increase in dopamine D(2) receptors in the ipsilateral striatum from 1 to 8 weeks of postlesion. In the ipsilateral substantia nigra (SN), a significant decrease in dopamine D(2) receptors was also observed from 1 to 8 weeks of postlesion. On the other hand, dopamine D(1) receptors were increased in the ipsilateral ventromedial striatum from 2 to 4 weeks of postlesion. In the ipsilateral SN, a transient increase in dopamine D(1) receptors was observed only 1 week after lesioning. However, other regions in both ipsilateral and contralateral sides showed no significant change in dopamine D(1) and D(2) receptors during postlesion except for a transient change in a few regions. N-Methyl-D-aspartate (NMDA) receptors showed no significant changes in all brain regions studied during the postlesion. In contrast, a transient increase in excitatory amino acid transport sites was observed only in the frontal cortex and ventromedial striatum of the ipsilateral side at 2 weeks of postlesion. However, glycine receptors showed a significant change in any brain areas of both ipsilateral and contralateral sides after lesioning. The change in the brain areas of contralateral side was more pronounced than that of ipsilateral side for glycine receptors. In addition, dopamine uptake sites showed a severe damage in the ipsilateral striatum from 1 to 8 weeks after lesioning. In the contralateral side, in contrast, no significant change in dopamine uptake sites was found in the striatum during the postlesion. These results indicate that unilateral injection of 6-hydroxydopamine in the medial forebrain bundle can cause a significant increase in dopamine D(1) and D(2) receptors in the striatum. The increase in dopamine D(2) receptors was more pronounced than that in dopamine D(1) receptors in the striatum after 6-hydroxydopamine treatment. In contrast, dopamine uptake sites showed a severe damage in the striatum during the postlesion. Furthermore, our results support the existence of dopamine D(2) receptors on the neurons of SN, but not dopamine D(1) receptors. For glutamatergic receptor system, the present study suggests that the changes in glycine receptors may be more susceptible to degeneration of nigrostriatal pathway than NMDA receptors and excitatory amino acid transport sites. Thus, our findings are of interest in relation of degeneration of the nigrostriatal pathway that occurs in Parkinson's disease" @default.
• W2016205531 created "2016-06-24" @default.
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• W2016205531 date "2000-09-01" @default.
• W2016205531 modified "2023-09-23" @default.
• W2016205531 title "Temporal changes of dopaminergic and glutamatergic receptors in 6-hydroxydopamine-treated rat brain" @default.
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• W2016205531 cites W1971465507 @default.
• W2016205531 cites W1976417177 @default.
• W2016205531 cites W1976528382 @default.
• W2016205531 cites W1979313228 @default.
• W2016205531 cites W1983878953 @default.
• W2016205531 cites W1985321201 @default.
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• W2016205531 cites W1990318285 @default.
• W2016205531 cites W1996498301 @default.
• W2016205531 cites W1997065612 @default.
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• W2016205531 cites W2003880585 @default.
• W2016205531 cites W2005102504 @default.
• W2016205531 cites W2010024285 @default.
• W2016205531 cites W2016512002 @default.
• W2016205531 cites W2018858628 @default.
• W2016205531 cites W2020171946 @default.
• W2016205531 cites W2020846299 @default.
• W2016205531 cites W2022711585 @default.
• W2016205531 cites W2022836134 @default.
• W2016205531 cites W2027323702 @default.
• W2016205531 cites W2030905853 @default.
• W2016205531 cites W2032667521 @default.
• W2016205531 cites W2038203809 @default.
• W2016205531 cites W2038380564 @default.
• W2016205531 cites W2041013190 @default.
• W2016205531 cites W2042066622 @default.
• W2016205531 cites W2042550512 @default.
• W2016205531 cites W2044556326 @default.
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• W2016205531 cites W2054216686 @default.
• W2016205531 cites W2054683291 @default.
• W2016205531 cites W2056798863 @default.
• W2016205531 cites W2057085877 @default.
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• W2016205531 doi "https://doi.org/10.1016/s0924-977x(00)00094-8" @default.
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