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- W2016205588 endingPage "1437" @default.
- W2016205588 startingPage "1423" @default.
- W2016205588 abstract "Protein tyrosine phosphatases have been the focus of considerable research efforts aimed at developing novel therapeutics; however, these targets are often characterized as being ‘undruggable’ due to the challenge of achieving selectivity, potency and cell permeability. More recently, there has been renewed interest in developing inhibitors of the tyrosine phosphatase SHP2 (PTPN11) in the light of its broad role in cancer, specifically juvenile myelomonocytic leukemia, and recent studies that implicate SHP2 as a key factor in breast cancer progression. Recent significant advances in the field of SHP2 inhibitor development raise the question: are we on the verge of a new era of protein tyrosine phosphatase-directed therapeutics? This article critically appraises recent developments, assesses ongoing challenges and presents a perspective on possible future directions." @default.
- W2016205588 created "2016-06-24" @default.
- W2016205588 creator A5005076023 @default.
- W2016205588 creator A5025099665 @default.
- W2016205588 creator A5034376733 @default.
- W2016205588 date "2014-08-01" @default.
- W2016205588 modified "2023-10-16" @default.
- W2016205588 title "Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention" @default.
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