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- W2016206030 endingPage "268" @default.
- W2016206030 startingPage "257" @default.
- W2016206030 abstract "MicroRNAs (miRNAs), widely distributed, small regulatory RNA genes, target both messenger RNA (mRNA) degradation and suppression of protein translation based on sequence complementarity between the miRNA and its targeted mRNA. Different names have been used to describe various types of miRNA. During evolution, RNA retroviruses or transgenes invaded the eukaryotic genome and inserted in the non-coding regions of DNA, conceivably acting as transposon-like jumping genes, providing defense from viral invasion and fine-tuning of gene expression as a secondary level of gene modulation in eukaryotes. When a transposon is inserted in the intron, it becomes an intronic miRNA, taking advantage of the protein synthesis machinery, i.e., mRNA transcription and splicing, as a means for processing and maturation. Recently, miRNAs have been found to play an important, but not life-threatening, role in embryonic development. They might play a pivotal role in diverse biological systems in various organisms, facilitating a quick response and accurate plotting of body physiology and structures. Based on these unique properties, man-made intronic miRNAs have been developed for in vitro evaluation of gene function, in vivo gene therapy and generation of transgenic animal models. The biogenesis and identification of miRNAs, potential applications, and future directions for research are presented, hopefully providing a guideline for further miRNA and gene function studies." @default.
- W2016206030 created "2016-06-24" @default.
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- W2016206030 date "2007-11-13" @default.
- W2016206030 modified "2023-10-17" @default.
- W2016206030 title "The MicroRNA (miRNA): Overview of the RNA Genes that Modulate Gene Function" @default.
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- W2016206030 cites W164713944 @default.
- W2016206030 cites W1958284284 @default.
- W2016206030 cites W1977733607 @default.
- W2016206030 cites W1980269624 @default.
- W2016206030 cites W1981453732 @default.
- W2016206030 cites W1986280646 @default.
- W2016206030 cites W198676265 @default.
- W2016206030 cites W1988528154 @default.
- W2016206030 cites W1989617912 @default.
- W2016206030 cites W1991524029 @default.
- W2016206030 cites W1991563094 @default.
- W2016206030 cites W1991935565 @default.
- W2016206030 cites W1993180746 @default.
- W2016206030 cites W1994674028 @default.
- W2016206030 cites W2001911979 @default.
- W2016206030 cites W2003632995 @default.
- W2016206030 cites W2007660972 @default.
- W2016206030 cites W2014064723 @default.
- W2016206030 cites W2015402753 @default.
- W2016206030 cites W2020914740 @default.
- W2016206030 cites W2026344530 @default.
- W2016206030 cites W2032323486 @default.
- W2016206030 cites W2037111014 @default.
- W2016206030 cites W2047988520 @default.
- W2016206030 cites W2060711522 @default.
- W2016206030 cites W2066118199 @default.
- W2016206030 cites W2068950572 @default.
- W2016206030 cites W2071596792 @default.
- W2016206030 cites W2071925802 @default.
- W2016206030 cites W2072155079 @default.
- W2016206030 cites W2073718731 @default.
- W2016206030 cites W2082213106 @default.
- W2016206030 cites W2090335107 @default.
- W2016206030 cites W2091966352 @default.
- W2016206030 cites W2095321031 @default.
- W2016206030 cites W2096196036 @default.
- W2016206030 cites W2097343134 @default.
- W2016206030 cites W2100581167 @default.
- W2016206030 cites W2101372151 @default.
- W2016206030 cites W2103028411 @default.
- W2016206030 cites W2105406908 @default.
- W2016206030 cites W2110017371 @default.
- W2016206030 cites W2110666579 @default.
- W2016206030 cites W2117648777 @default.
- W2016206030 cites W2117895751 @default.
- W2016206030 cites W2120778382 @default.
- W2016206030 cites W2127497651 @default.
- W2016206030 cites W2129232563 @default.
- W2016206030 cites W2135837360 @default.
- W2016206030 cites W2138664009 @default.
- W2016206030 cites W2138708625 @default.
- W2016206030 cites W2139791626 @default.
- W2016206030 cites W2140446903 @default.
- W2016206030 cites W2144071128 @default.
- W2016206030 cites W2146900615 @default.
- W2016206030 cites W2147694813 @default.
- W2016206030 cites W2149291473 @default.
- W2016206030 cites W2152993806 @default.
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- W2016206030 cites W2155618135 @default.
- W2016206030 cites W2157978879 @default.
- W2016206030 cites W2159558399 @default.
- W2016206030 cites W2166179294 @default.
- W2016206030 cites W2167557255 @default.
- W2016206030 cites W2168230240 @default.
- W2016206030 cites W2342051973 @default.
- W2016206030 cites W4234236052 @default.
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- W2016206030 doi "https://doi.org/10.1007/s12033-007-9013-8" @default.
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