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• W2016206569 endingPage "73" @default.
• W2016206569 startingPage "61" @default.
• W2016206569 abstract "T10B9.1A-31 is an immunoglobulin Mk (lgMk), CD3b class, murine monoclonal antibody. It is not itself mitogenic, but it partially blocks mitogenesis produced by concanavilin-A, phytohemagglutinin, and a soluble antigen cocktail and is lytic for human peripheral blood T lymphocytes (PB-T) in the presence of fresh autologous human complement and rabbit complement. It reacts with a monomorphic epitope found on all mature PB-Ts that modulates in vitro and in vivo with the CD3/T-cell antigen receptor (TCR) complex, but unlike OKT3, which reacts with CD3 proteins, T10B9.1A-31 reacts with an epitope of the TCR alpha/beta heterodimer. Immunoprecipitation of HPB-ALL with T10B9.1A-31 or OKT3 revealed that T10B9.1A-31 does not react with the 20-to 26-kd polypeptides that compose CD3, and T10B9.1A-31 failed to bind to the PEER cell, which is CD3 gamma/delta positive, TCR alpha/beta negative. Phase 1 clinical trials demonstrated that T10B9.1A-31 caused a rapid decrease in PB-Ts and no toxic effects other than fever, chills, rigors, and transient hypotension. These side effects were absent in methylprednisolone (MP)-pretreated patients. Phase II studies revealed that T10B9.1A-31 reversed steroid refractory acute rejection in three of five renal allografts treated with cyclosporine (CyA) and prednisone (P) maintenance immunosuppression, reversed steroid and polyclonal antisera refractory rejection in three cardiac allograft recipients receiving CyA/P, and attenuated acute rejection in three of three renal patients receiving baseline azathioprine/prednisone (AZA/P) when used as primary therapy. Rerejection was not seen when patients received CyA baseline immunosuppression but was seen in patients maintained on AZA/P OKT3 was efficacious in treating rejection following T10B9.1A-31 therapy. Side effects of T10B9.1A-31 appears to reverse acute rejection crisis effectively in renal and cardiac transplantation with a low incidence of rerejection in CyA-maintained patients and with fewer, milder side effects. Sequential therapy with OKT3 is possible because OKT3 and T10B9.1A-31 are of different isotypes and idiotypes." @default.
• W2016206569 created "2016-06-24" @default.
• W2016206569 creator A5074422501 @default.
• W2016206569 creator A5078304984 @default.
• W2016206569 date "1989-07-01" @default.
• W2016206569 modified "2023-09-25" @default.
• W2016206569 title "Physiology and Cell Biology Update: Polypeptide Growth Factors and Their Relation to Renal Disease" @default.
• W2016206569 cites W1496494806 @default.
• W2016206569 cites W1501383613 @default.
• W2016206569 cites W1505978562 @default.
• W2016206569 cites W1507961261 @default.
• W2016206569 cites W1509400195 @default.
• W2016206569 cites W1509427422 @default.
• W2016206569 cites W1511815713 @default.
• W2016206569 cites W1515935875 @default.
• W2016206569 cites W1521573047 @default.
• W2016206569 cites W1541401066 @default.
• W2016206569 cites W1865845936 @default.
• W2016206569 cites W1867003241 @default.
• W2016206569 cites W1894641937 @default.
• W2016206569 cites W1964676918 @default.
• W2016206569 cites W1965896882 @default.
• W2016206569 cites W1970516412 @default.
• W2016206569 cites W1977206006 @default.
• W2016206569 cites W1978414947 @default.
• W2016206569 cites W1980929739 @default.
• W2016206569 cites W1982251557 @default.
• W2016206569 cites W1984223466 @default.
• W2016206569 cites W1984615430 @default.
• W2016206569 cites W1984797080 @default.
• W2016206569 cites W1985401404 @default.
• W2016206569 cites W1992172901 @default.
• W2016206569 cites W1992327323 @default.
• W2016206569 cites W1994341785 @default.
• W2016206569 cites W1996683778 @default.
• W2016206569 cites W1997556974 @default.
• W2016206569 cites W1998329643 @default.
• W2016206569 cites W2001488986 @default.
• W2016206569 cites W2002224275 @default.
• W2016206569 cites W2003178930 @default.
• W2016206569 cites W2004179558 @default.
• W2016206569 cites W2005668137 @default.
• W2016206569 cites W2007726262 @default.
• W2016206569 cites W2007768242 @default.
• W2016206569 cites W2009038572 @default.
• W2016206569 cites W2009928329 @default.
• W2016206569 cites W2011247974 @default.
• W2016206569 cites W2012845298 @default.
• W2016206569 cites W2016568386 @default.
• W2016206569 cites W2017347652 @default.
• W2016206569 cites W2018125085 @default.
• W2016206569 cites W2019829774 @default.
• W2016206569 cites W2023267392 @default.
• W2016206569 cites W2024528924 @default.
• W2016206569 cites W2024787221 @default.
• W2016206569 cites W2030534014 @default.
• W2016206569 cites W2032512261 @default.
• W2016206569 cites W2035033788 @default.
• W2016206569 cites W2035563619 @default.
• W2016206569 cites W2037073313 @default.
• W2016206569 cites W2043184584 @default.
• W2016206569 cites W2043727319 @default.
• W2016206569 cites W2044917338 @default.
• W2016206569 cites W2048067020 @default.
• W2016206569 cites W2051381725 @default.
• W2016206569 cites W2059527338 @default.
• W2016206569 cites W2060671733 @default.
• W2016206569 cites W2062199188 @default.
• W2016206569 cites W2065418754 @default.
• W2016206569 cites W2069436261 @default.
• W2016206569 cites W2072523592 @default.
• W2016206569 cites W2074422825 @default.
• W2016206569 cites W2074511156 @default.
• W2016206569 cites W2075254346 @default.
• W2016206569 cites W2080350413 @default.
• W2016206569 cites W2080620426 @default.
• W2016206569 cites W2082677148 @default.
• W2016206569 cites W2084523333 @default.
• W2016206569 cites W2085806876 @default.
• W2016206569 cites W2087863947 @default.
• W2016206569 cites W2088435625 @default.
• W2016206569 cites W2095147770 @default.
• W2016206569 cites W2095549623 @default.
• W2016206569 cites W2102123572 @default.
• W2016206569 cites W2103463013 @default.
• W2016206569 cites W2103824972 @default.
• W2016206569 cites W2104573605 @default.
• W2016206569 cites W2108104357 @default.
• W2016206569 cites W2110623508 @default.
• W2016206569 cites W2112436512 @default.
• W2016206569 cites W2114668163 @default.
• W2016206569 cites W2115453867 @default.
• W2016206569 cites W2119643278 @default.
• W2016206569 cites W2128888654 @default.
• W2016206569 cites W2139401320 @default.
• W2016206569 cites W2145481755 @default.
• W2016206569 cites W2148371225 @default.
• W2016206569 cites W2157245781 @default.

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