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- W2016208410 endingPage "12" @default.
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- W2016208410 abstract "Epidermal growth factor receptor (EGFR) is one of the most commonly altered genes in human cancer by way of over-expression, amplification, and mutation. Targeted inhibition of EGFR activity suppresses signal transduction pathways which control tumor cell growth, proliferation, and resistance to apoptosis. Small molecule tyrosine kinase inhibitors and monoclonal antibodies are among the most common EGFR-targeting agents and have been used clinically for treating various malignancies. This review discusses the successes and challenges of targeting EGFR in human cancer. The genetic alterations of EGFR tend to occur more often in some solid tumors than others, as do the mechanisms of resistance to targeted inhibition. The clinical and basic science experiences with these agents thus far have important implications for the future of therapeutic targeting of EGFR." @default.
- W2016208410 created "2016-06-24" @default.
- W2016208410 creator A5021214185 @default.
- W2016208410 creator A5036647593 @default.
- W2016208410 creator A5072507966 @default.
- W2016208410 creator A5080403474 @default.
- W2016208410 date "2011-01-05" @default.
- W2016208410 modified "2023-10-14" @default.
- W2016208410 title "Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations" @default.
- W2016208410 cites W1581824974 @default.
- W2016208410 cites W1599518523 @default.
- W2016208410 cites W1957565841 @default.
- W2016208410 cites W1966803171 @default.
- W2016208410 cites W1974024530 @default.
- W2016208410 cites W1974423469 @default.
- W2016208410 cites W1978177843 @default.
- W2016208410 cites W1979332174 @default.
- W2016208410 cites W1981078630 @default.
- W2016208410 cites W1984852348 @default.
- W2016208410 cites W1988442083 @default.
- W2016208410 cites W1995337883 @default.
- W2016208410 cites W1998971866 @default.
- W2016208410 cites W1999824494 @default.
- W2016208410 cites W2000386698 @default.
- W2016208410 cites W2001276579 @default.
- W2016208410 cites W2003984225 @default.
- W2016208410 cites W2004439203 @default.
- W2016208410 cites W2007393641 @default.
- W2016208410 cites W2014956732 @default.
- W2016208410 cites W2016568386 @default.
- W2016208410 cites W2018217352 @default.
- W2016208410 cites W2022039831 @default.
- W2016208410 cites W2025183726 @default.
- W2016208410 cites W2026727845 @default.
- W2016208410 cites W2032644486 @default.
- W2016208410 cites W2037581548 @default.
- W2016208410 cites W2043696829 @default.
- W2016208410 cites W2043911313 @default.
- W2016208410 cites W2046802065 @default.
- W2016208410 cites W2048578230 @default.
- W2016208410 cites W2048758017 @default.
- W2016208410 cites W2049182264 @default.
- W2016208410 cites W2049292021 @default.
- W2016208410 cites W2060157525 @default.
- W2016208410 cites W2060950200 @default.
- W2016208410 cites W2064047613 @default.
- W2016208410 cites W2064283997 @default.
- W2016208410 cites W2064548992 @default.
- W2016208410 cites W2069907205 @default.
- W2016208410 cites W2070705072 @default.
- W2016208410 cites W2073557222 @default.
- W2016208410 cites W2079677696 @default.
- W2016208410 cites W2086224272 @default.
- W2016208410 cites W2091707974 @default.
- W2016208410 cites W2093613683 @default.
- W2016208410 cites W2095327431 @default.
- W2016208410 cites W2095541301 @default.
- W2016208410 cites W2095618958 @default.
- W2016208410 cites W2097121246 @default.
- W2016208410 cites W2097331713 @default.
- W2016208410 cites W2097698108 @default.
- W2016208410 cites W2100490225 @default.
- W2016208410 cites W2101322783 @default.
- W2016208410 cites W2103334409 @default.
- W2016208410 cites W2103894337 @default.
- W2016208410 cites W2104743043 @default.
- W2016208410 cites W2106161829 @default.
- W2016208410 cites W2106789440 @default.
- W2016208410 cites W2109080255 @default.
- W2016208410 cites W2109106857 @default.
- W2016208410 cites W2109528706 @default.
- W2016208410 cites W2110425570 @default.
- W2016208410 cites W2110841878 @default.
- W2016208410 cites W2113544944 @default.
- W2016208410 cites W2114523583 @default.
- W2016208410 cites W2115131874 @default.
- W2016208410 cites W2122885616 @default.
- W2016208410 cites W2125229905 @default.
- W2016208410 cites W2128059540 @default.
- W2016208410 cites W2131413118 @default.
- W2016208410 cites W2131928389 @default.
- W2016208410 cites W2134519717 @default.
- W2016208410 cites W2136822754 @default.
- W2016208410 cites W2137605317 @default.
- W2016208410 cites W2138297714 @default.
- W2016208410 cites W2139799027 @default.
- W2016208410 cites W2140334822 @default.
- W2016208410 cites W2140375000 @default.
- W2016208410 cites W2140407529 @default.
- W2016208410 cites W2142564546 @default.
- W2016208410 cites W2146909958 @default.
- W2016208410 cites W2151335185 @default.
- W2016208410 cites W2153477391 @default.
- W2016208410 cites W2155384808 @default.
- W2016208410 cites W2158134441 @default.
- W2016208410 cites W2159013299 @default.
- W2016208410 cites W2161422104 @default.
- W2016208410 cites W2161821474 @default.