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• W2016208766 abstract "The nurse cell (NC), formed from muscle cells upon infection with the parasitic nematode Trichinella spp. constitutes a confined habitat for muscle larvae of encapsulating species. Signaling pathway-directed analysis of microarray data allowed identification of the stage of NC cell cycle arrest as being of G1-like type, accompanied by cellular senescence. In accord with the specificity of senescent cellular systems, up-regulation of pro-inflammatory molecules was also found within the NC preparations. Potential immune-related activities associated with NCs as inferred from the aforementioned analysis, are reviewed herein. Transcriptional data suggest that the NC which harbors the larvae may exhibit the following immune-related functions: (i) production of complement components, (ii) antigen presentation and phagocytosis, (iii) pro-inflammatory cytokine secretion, (iv) oxidative stress generation and (v) eicosanoid synthesis." @default.
• W2016208766 created "2016-06-24" @default.
• W2016208766 creator A5041965541 @default.
• W2016208766 date "2013-05-01" @default.
• W2016208766 modified "2023-10-01" @default.
• W2016208766 title "Inflammatory phenotype of the nurse cell harboring Trichinella spp." @default.
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• W2016208766 doi "https://doi.org/10.1016/j.vetpar.2013.01.043" @default.
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