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- W2016208891 abstract "In order to further advance our knowledge of the role epidermal growth factor (EGF) plays in thyroid carcinoma, we investigated its effect on the regulation of matrix metalloproteinase-9 (MMP-9), a key enzyme that plays an important role in tumor invasion and angiogenesis. The expression of MMP-9 in EGF-treated and untreated human follicular thyroid carcinoma cells (FTC-133) was evaluated using reverse transcription–PCR, Western blot and gelatin zymography. Transient transfection and electrophoretic mobility shift assays (EMSA) were also performed to measure MMP-9 promoter activity, to identify multiple signaling pathways and to determine a proximal AP-1-binding site located between −79 to −73 base pairs upstream of the transcriptional start site that is involved in activation of MMP-9 by EGF. In the present study, we demonstrate that EGF treatment up-regulated MMP-9 expression in human follicular thyroid carcinoma cells. Expression of FAK-related non kinase (FRNK), a potent dominant-negative inhibitor of FAK, reduced FAK auto-phosphorylation and inhibited EGF-induced MMP-9 transcription and secretion leading to decreased cell invasion through Matrigel in in vitro Transwell assays. Our studies highlight the role FAK plays in promoting cell invasion through the activation of distinct signaling pathways induced by EGF with protein MMP-9 transcription and secretion in follicular thyroid carcinoma cells." @default.
- W2016208891 created "2016-06-24" @default.
- W2016208891 creator A5024115942 @default.
- W2016208891 creator A5025178738 @default.
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- W2016208891 date "2007-05-01" @default.
- W2016208891 modified "2023-10-04" @default.
- W2016208891 title "Epidermal growth factor stimulates matrix metalloproteinase-9 expression and invasion in human follicular thyroid carcinoma cells through Focal adhesion kinase" @default.
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- W2016208891 doi "https://doi.org/10.1016/j.biochi.2007.01.015" @default.
- W2016208891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17397984" @default.
- W2016208891 hasPublicationYear "2007" @default.