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• W2016209500 abstract "Publisher Summary This chapter describes the collaborative psychopharmacologic studies exploring catecholamine metabolism in psychiatric disorders. Studies of amines and their metabolites in cerebrospinal fluid (CSF), likely represent the most direct available means for evaluating amine metabolism in the human subject. The occurrence of 3-methoxy-4-hydroxyphenyl glycol (MHPG) in CSF has been documented. A longitudinal study was carried out in three depressed females and one male manic patient in an attempt to monitor changes in urinary MHPG with change in clinical state during drug treatment. In the manic individual, MHPG levels were measured both in mg/24 h, and by μg/mg creatinine for comparison. In the three depressed females, and despite the marked variability in daily urinary MHPG, all values were within the normal range throughout the study. Two of the depressives showed psychomotor retardation, the third was agitated, and all three individuals showed symptom improvement on imipramine with total remission on 300 mg by the third week of study. The MHPG excretion was generally low in the manic patient during 3 weeks of treatment with chlorpromazine: he was severely manic throughout." @default.
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• W2016209500 date "1974-04-01" @default.
• W2016209500 modified "2023-09-27" @default.
• W2016209500 title "Collaborative psychopharmacologic studies exploring catecholamine metabolism in psychiatric disorders" @default.
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• W2016209500 doi "https://doi.org/10.1016/0006-2952(74)90173-7" @default.
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