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- W2016223612 abstract "Abstract Two groups of investigators have used the classical model for the distribution of thiopental following iv injection to predict the distribution of dieldrin following accidental ingestion. They concluded that the concentration of dieldrin in the brain is reduced first by redistribution to muscle and only later by redistribution to fat. The model as originally designed for thiopental had been evaluated by analysis of samples from persons undergoing surgery under thiopental anesthesia. Since it is not appropriate to give large doses of dieldrin to humans or to collect samples of muscle and various vital organs from them, the distribution of dieldrin was studied in rats. Dieldrin dissolved in corn oil was administered to these animals by stomach tube. The highest concentration of dieldrin in the brain was reached in 4 hr, and the concentration decreased gradually thereafter. The concentration in muscle remained essentially steady during the interval from 4 to 48 hr. There was no peak for muscle that could be interpreted as replacing a peak for brain. The concentration of dieldrin in fat was already slightly higher than that in the brain at 1 hr, very much higher at 4 hr when the concentration in the brain was maximal, and the concentration in the fat continued to increase during the first 24 hr. Either on the basis of concentration or on the basis of the total amount in each organ, no reason was found to assign any special importance to muscle as a sink into which dieldrin is redistributed from the brain. The fat appears to be far more important in this regard. The results indicate the danger of applying a mathematical model to a new situation without checking the results experimentally." @default.
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- W2016223612 date "1974-06-01" @default.
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- W2016223612 title "Distribution of dieldrin following a single oral dose" @default.
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- W2016223612 doi "https://doi.org/10.1016/0041-008x(74)90233-6" @default.
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